Cellular mechanotransduction: from tension to function

F Martino, AR Perestrelo, V Vinarský, S Pagliari… - Frontiers in …, 2018 - frontiersin.org
Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

The cytoskeleton—a complex interacting meshwork

T Hohmann, F Dehghani - Cells, 2019 - mdpi.com
The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

[HTML][HTML] Vimentin on the move: new developments in cell migration

RA Battaglia, S Delic, H Herrmann, NT Snider - F1000Research, 2018 - ncbi.nlm.nih.gov
The vimentin gene (VIM) encodes one of the 71 human intermediate filament (IF) proteins,
which are the building blocks of highly ordered, dynamic, and cell type-specific fiber …

[HTML][HTML] Actin flows mediate a universal coupling between cell speed and cell persistence

P Maiuri, JF Rupprecht, S Wieser, V Ruprecht… - Cell, 2015 - cell.com
Cell movement has essential functions in development, immunity, and cancer. Various cell
migration patterns have been reported, but no general rule has emerged so far. Here, we …

Cell migration guided by long-lived spatial memory

J d'Alessandro, A Barbier--Chebbah, V Cellerin… - Nature …, 2021 - nature.com
Living cells actively migrate in their environment to perform key biological functions—from
unicellular organisms looking for food to single cells such as fibroblasts, leukocytes or …

Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions

SI Fraley, P Wu, L He, Y Feng, R Krisnamurthy… - Scientific reports, 2015 - nature.com
Multiple attributes of the three-dimensional (3D) extracellular matrix (ECM) have been
independently implicated as regulators of cell motility, including pore size, crosslink density …

Deposited footprints let cells switch between confined, oscillatory, and exploratory migration

E Perez Ipiña, J d'Alessandro… - Proceedings of the …, 2024 - National Acad Sciences
For eukaryotic cells to heal wounds, respond to immune signals, or metastasize, they must
migrate, often by adhering to extracellular matrix (ECM). Cells may also deposit ECM …

Actin flows in cell migration: from locomotion and polarity to trajectories

AC Callan-Jones, R Voituriez - Current opinion in cell biology, 2016 - Elsevier
Eukaryotic cell movement is characterized by very diverse migration modes. Recent studies
show that cells can adapt to environmental cues, such as adhesion and geometric …

The self-organization of plant microtubules inside the cell volume yields their cortical localization, stable alignment, and sensitivity to external cues

V Mirabet, P Krupinski, O Hamant… - PLoS computational …, 2018 - journals.plos.org
Many cell functions rely on the ability of microtubules to self-organize as complex networks.
In plants, cortical microtubules are essential to determine cell shape as they guide the …

Periodicity, mixed-mode oscillations, and multiple timescales in a phosphoinositide-Rho GTPase network

C San Tong, XJ Xǔ, M Wu - Cell Reports, 2023 - cell.com
While rhythmic contractile behavior is commonly observed at the cellular cortex, the primary
focus has been on excitable or periodic events described by simple activator-delayed …