Background: Patients with diabetes mellitus need information about the effectiveness of
innovations in insulin delivery and glucose monitoring. Purpose: To review how intensive …

Background Type 1 diabetes is a metabolic disorder resulting from a defect in insulin
secretion. Onset of type 1 diabetes mellitus may occur at any age and it is one of the most …

Objective: To formulate clinical practice guidelines for the use of continuous glucose
monitoring and continuous subcutaneous insulin infusion in adults with diabetes …

Overall lowering of glucose is of pivotal importance in the treatment of diabetes, with proven
beneficial effects on microvascular and macrovascular outcomes. Still, patients with similar …

A 39-year-old man with type 1 diabetes mellitus is referred for consideration of insulin-pump
therapy because of poor glycemic control and episodes of severe hypoglycemia. Insulin …

OBJECTIVE To compare the improvements in glycemic control associated with transitioning
to insulin pump therapy in patients using continuous glucose monitoring versus standard …

Context: Hypoglycemia limits the efficacy of intensive insulin therapy. The extent to which
continuous insulin infusion (CSII) overcomes this limitation is unclear. Objective: The aim …

Accumulating evidence indicates the occurrence and development of diabetic complications
relates to not only constant high plasma glucose, but also glucose fluctuations which affect …

The relative efficacy of continuous subcutaneous insulin infusion and multiple daily
injections in individuals with type 1 diabetes is unclear. We sought to synthesize the existing …

The discovery of insulin and its clinical application early in the last century dramatically
improved the prospects of people with diabetes. However, the limitations of those initial …