Imaging hypoxia to improve radiotherapy outcome

MR Horsman, LS Mortensen, JB Petersen… - Nature reviews Clinical …, 2012 - nature.com
Reduced oxygen levels (hypoxia) is one of the most important factors influencing clinical
outcome after radiotherapy. This is primarily because hypoxic cells are resistant to radiation …

The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities

C WalshJoseph, C KolbHartmuth - Antioxidants & redox signaling, 2014 - liebertpub.com
Tumor hypoxia is a well-established biological phenomenon that affects the curability of
solid tumors, regardless of treatment modality. Especially for head and neck cancer patients …

Models and methods for analyzing DCE‐MRI: A review

F Khalifa, A Soliman, A El‐Baz… - Medical …, 2014 - Wiley Online Library
Purpose: To present a review of most commonly used techniques to analyze dynamic
contrast‐enhanced magnetic resonance imaging (DCE‐MRI), discusses their strengths and …

Hypoxia in cancer: significance and impact on clinical outcome

P Vaupel, A Mayer - Cancer and Metastasis Reviews, 2007 - Springer
Hypoxia, a characteristic feature of locally advanced solid tumors, has emerged as a pivotal
factor of the tumor (patho-) physiome since it can promote tumor progression and resistance …

Nanoscale metal–organic frameworks for ratiometric oxygen sensing in live cells

R Xu, Y Wang, X Duan, K Lu, D Micheroni… - Journal of the …, 2016 - ACS Publications
We report the design of a phosphorescence/fluorescence dual-emissive nanoscale metal–
organic framework (NMOF), R-UiO, as an intracellular oxygen (O2) sensor. R-UiO contains a …

[HTML][HTML] Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (IV): Basic principles and parameters for MR imaging within the frame of image …

JCA Dimopoulos, P Petrow, K Tanderup… - Radiotherapy and …, 2012 - Elsevier
The GYN GEC-ESTRO working group issued three parts of recommendations and
highlighted the pivotal role of MRI for the successful implementation of 3D image-based …

Detection and Characterization of Tumor Hypoxia Using pO2 Histography

P Vaupel, M Höckel, A Mayer - Antioxidants & redox signaling, 2007 - liebertpub.com
Data from 125 studies describing the pretreatment oxygenation status as measured in the
clinical setting using the computerized Eppendorf pO2 histography system have been …

Dynamic contrast‐enhanced MRI in clinical oncology: current status and future directions

AR Padhani - Journal of Magnetic Resonance Imaging: An …, 2002 - Wiley Online Library
Dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) is performed after the
administration of intravenous contrast medium to noninvasively access tumor vascular …

Functional tumor imaging with dynamic contrast‐enhanced magnetic resonance imaging

PL Choyke, AJ Dwyer, MV Knopp - Journal of Magnetic …, 2003 - Wiley Online Library
Dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) is the acquisition of
serial MRI images before, during, and after the administration of an MR contrast agent …

Intra-tumoural microvessel density in human solid tumours

J Hasan, R Byers, GC Jayson - British journal of cancer, 2002 - nature.com
Over the last decade assessment of angiogenesis has emerged as a potentially useful
biological prognostic and predictive factor in human solid tumours. With the development of …