Reduced oxygen levels (hypoxia) is one of the most important factors influencing clinical
outcome after radiotherapy. This is primarily because hypoxic cells are resistant to radiation …

Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its
association with an aggressive tumour phenotype and therapeutic resistance. Given its …

Hypoxia, a characteristic feature of locally advanced solid tumors, has emerged as a pivotal
factor of the tumor (patho-) physiome since it can promote tumor progression and resistance …

Hypoxia is a pathological condition arising in living tissues when oxygen supply does not
adequately cover the cellular metabolic demand. Detection of this phenomenon in tumors is …

Purpose Hypoxia is a condition of insufficient oxygen to support metabolism which occurs
when the vascular supply is interrupted, or when a tumour outgrows its vascular supply. It is …

Tissue hypoxia results from an inadequate supply of oxygen (O 2) that compromises
biological functions. Structural and functional abnormalities of the tumour vasculature …

Quantitative imaging biomarkers show great potential for use in radiotherapy. Quantitative
images based on microscopic tissue properties and tissue function can be used to improve …

The hypoxic state in a solid tumor refers to the internal hypoxic environment that appears as
the tumor volume increases (the maximum radius exceeds 180-200 microns). This state can …

Abstract Ljungkvist, ASE, Bussink, J., Kaanders, JHAM and van der Kogel, AJ Dynamics of
Tumor Hypoxia Measured with Bioreductive Hypoxic Cell Markers. Radiat. Res. 167, 127 …

A method is presented to identify and quantify hypoxia in human head-and-neck tumours
based on dynamic [18 F]-Fmiso PET patient data, using a model for the tracer transport. A …