Benzotriazole: An overview on its versatile biological behavior
I Briguglio, S Piras, P Corona, E Gavini… - European Journal of …, 2015 - Elsevier
Discovered in late 1960, azoles are heterocyclic compounds class which constitute the
largest group of available antifungal drugs. Particularly, the imidazole ring is the chemical …
largest group of available antifungal drugs. Particularly, the imidazole ring is the chemical …
Bioactive 1, 2, 3‐Triazoles: An Account on their Synthesis, Structural Diversity and Biological Applications
L da SM Forezi, CGS Lima, AAP Amaral… - The Chemical …, 2021 - Wiley Online Library
The triazole heterocycle is a privileged scaffold in medicinal chemistry, since its structure is
present in a large number of biologically active molecules, including several drugs currently …
present in a large number of biologically active molecules, including several drugs currently …
Hybrid compounds as direct multitarget ligands: a review
M Oliveira Pedrosa, RM Duarte da Cruz… - Current topics in …, 2017 - ingentaconnect.com
Molecular Hybridization is an approach in rational drug design where new chemical entities
are obtained by combining two or more pharmacophoric units from different bioactive …
are obtained by combining two or more pharmacophoric units from different bioactive …
Synthesis of new thiazolyl-pyrazolyl-1, 2, 3-triazole derivatives as potential antimicrobial agents
A series of 1-substituted benzyl-4-[1-phenyl-3-(4-methyl-2-aryl-1, 3-thiazol-5-yl)-1H-pyrazol-
4-yl]-1H-1, 2, 3-triazole derivatives (7a-y) have been synthesized by click reaction of 5-(4 …
4-yl]-1H-1, 2, 3-triazole derivatives (7a-y) have been synthesized by click reaction of 5-(4 …
Thiazolyl-pyrazole derivatives as potential antimycobacterial agents
SJ Takate, AD Shinde, BK Karale, H Akolkar… - Bioorganic & Medicinal …, 2019 - Elsevier
Mycobacterium tuberculosis (Mtb) is an obligate aerobe that is capable of long-term
persistence under conditions of low oxygen tension. A series of thiazolyl-pyrazole …
persistence under conditions of low oxygen tension. A series of thiazolyl-pyrazole …
A novel series of thiazolyl–pyrazoline derivatives: Synthesis and evaluation of antifungal activity, cytotoxicity and genotoxicity
In the current work, new thiazolyl–pyrazoline derivatives (1–22) were synthesized and
evaluated for their antifungal effects against pathogenic yeasts and molds using a broth …
evaluated for their antifungal effects against pathogenic yeasts and molds using a broth …
Design, synthesis and biological activity of hybrid antifungals derived from fluconazole and mebendazole
A novel series of triazole alcohol antifungals bearing a 5-benzoylbenzimidazol-2-ylthio side
chain have been designed and synthesized as hybrids of fluconazole (a typical triazole …
chain have been designed and synthesized as hybrids of fluconazole (a typical triazole …
Novel 1H-1,2,3-, 2H-1,2,3-, 1H-1,2,4- and 4H-1,2,4-triazole derivatives: a patent review (2008 – 2011)
Introduction: The triazoles represent a class of five-membered heterocyclic compounds of
great importance for the preparation of new drugs with diverse biological activities because …
great importance for the preparation of new drugs with diverse biological activities because …
Synthesis and antimicrobial evaluation of new thiazolyl-1, 2, 3-triazolyl-alcohol derivatives
S Jagadale, A Chavan, A Shinde, V Sisode… - Medicinal Chemistry …, 2020 - Springer
Abstract A new series of 1-(4-methyl-2-aryl-1, 3-thiazol-5-yl)-2-(4-aryl-1, 2, 3-triazol-1-yl)
ethanol (6a-t) have been synthesized by a click reaction of 2-azido-1-(4-methyl-2 …
ethanol (6a-t) have been synthesized by a click reaction of 2-azido-1-(4-methyl-2 …
[HTML][HTML] New hydrazones bearing thiazole scaffold: Synthesis, characterization, antimicrobial, and antioxidant investigation
New series of hydrazones 5–18 were synthesized, in good yields, by reacting 4-methyl-2-(4-
(trifluoromethyl) phenyl) thiazole-5-carbohydrazide with differently substituted …
(trifluoromethyl) phenyl) thiazole-5-carbohydrazide with differently substituted …