Discovered in late 1960, azoles are heterocyclic compounds class which constitute the
largest group of available antifungal drugs. Particularly, the imidazole ring is the chemical …

The triazole heterocycle is a privileged scaffold in medicinal chemistry, since its structure is
present in a large number of biologically active molecules, including several drugs currently …

Molecular Hybridization is an approach in rational drug design where new chemical entities
are obtained by combining two or more pharmacophoric units from different bioactive …

A series of 1-substituted benzyl-4-[1-phenyl-3-(4-methyl-2-aryl-1, 3-thiazol-5-yl)-1H-pyrazol-
4-yl]-1H-1, 2, 3-triazole derivatives (7a-y) have been synthesized by click reaction of 5-(4 …

Mycobacterium tuberculosis (Mtb) is an obligate aerobe that is capable of long-term
persistence under conditions of low oxygen tension. A series of thiazolyl-pyrazole …

In the current work, new thiazolyl–pyrazoline derivatives (1–22) were synthesized and
evaluated for their antifungal effects against pathogenic yeasts and molds using a broth …

A novel series of triazole alcohol antifungals bearing a 5-benzoylbenzimidazol-2-ylthio side
chain have been designed and synthesized as hybrids of fluconazole (a typical triazole …

Introduction: The triazoles represent a class of five-membered heterocyclic compounds of
great importance for the preparation of new drugs with diverse biological activities because …

Abstract A new series of 1-(4-methyl-2-aryl-1, 3-thiazol-5-yl)-2-(4-aryl-1, 2, 3-triazol-1-yl)
ethanol (6a-t) have been synthesized by a click reaction of 2-azido-1-(4-methyl-2 …

New series of hydrazones 5–18 were synthesized, in good yields, by reacting 4-methyl-2-(4-
(trifluoromethyl) phenyl) thiazole-5-carbohydrazide with differently substituted …