The meaning of gene therapy is the delivery of DNA or RNA to cells for the treatment or
prevention of genetic disorders. The success rate of gene therapy depends on the …

Bone injuries and diseases constitute a burden both socially and economically, as the
consequences of a lack of effective treatments affect both the patients' quality of life and the …

Engineering a pro-regenerative immune response following scaffold implantation is integral
to functional tissue regeneration. The immune response to implanted biomaterials is …

Therapeutic growth factor delivery typically requires supraphysiological dosages, which can
cause undesirable off-target effects. The aim of this study was to 3D bioprint implants …

Background The role of bone tissue engineering in the field of regenerative medicine has
been a main research topic over the past few years. There has been much interest in the use …

The regeneration of complex tissues and organs remains a major clinical challenge. With a
view towards bioprinting such tissues, we developed a new class of pore-forming bioink to …

Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery.
The ideal treatment for such tissue loss is autografting, but donor sites are often limited …

Abstract Background Mesenchymal stem cells (MSCs) are multipotent stem cells that can be
isolated and expanded from many tissues, and are being investigated for use in cell …

Gene therapy is a promising novel method of tissue regeneration by stimulating or inhibiting
key signaling pathways. However, their therapeutic applications in vivo are largely limited by …

There is an urgent, clinical need for an alternative to the use of autologous grafts for the ever
increasing number of bone grafting procedures performed annually. Herein, we describe a …