The role of histone post-translational modifications (PTMs) in chromatin structure and
genome function has been the subject of intense debate for more than 60 years. Though …

Maintaining stability of the genome requires dedicated DNA repair and signalling processes
that are essential for the faithful duplication and propagation of chromosomes. These DNA …

Histone post-translational modifications (PTMs) play a critical role in chromatin regulation. It
has been proposed that these PTMs form localized 'codes' that are read by specialized …

Epigenetic regulators have a crucial effect on gene expression based on their manipulation
of histone modifications. Histone H2AK119 monoubiquitination (H2AK119Ub), a well …

Introduction: A previous study of 200,000 exome-sequenced UK Biobank participants to test
for association of rare coding variants with hypertension implicated two genes at exome …

A dynamic array of histone post-translational modifications (PTMs) regulate diverse cellular
processes in the eukaryotic chromatin. Among them, histone ubiquitination is particularly …

The circulatory system is a closed conduit system throughout the body and consists of two
parts as follows: the cardiovascular system and the lymphatic system. Hematological …

Chromatin regulators are a group of proteins that can alter the physical properties of
chromatin to make it more or less permissive to transcription by modulating another protein's …

Nucleosomes are the fundamental unit of eukaryotic chromatin. Diverse factors interact with
nucleosomes to modulate chromatin architecture and facilitate DNA repair, replication …

The attachment of mono-ubiquitin to histones as a post-translational modification plays
important roles in regulating chromatin structure and function. Like other epigenetic …