In addition to the anti-diabetic effect of metformin, a growing number of studies have shown
that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer …

Metformin, as a dimethyl biguanide prescribed as the first-line medication for treatment of
type 2 diabetes mellitus, is one of the most frequently used drugs, worldwide. However, the …

Methotrexate (MTX) is a drug which is used to treat different types of cancers but
hepatotoxicity limits its clinical use. Chlorogenic acid (CGA) is one of the most abundant …

Metformin is the first-line drug in the treatment of type 2 diabetes. In addition to its
hypoglycemic effect, metformin has an anti-inflammatory function, but the precise …

AIM: To investigate the potential role of oxidative stress and the possible therapeutic effects
of N-acetyl cysteine (NAC), amifostine (AMF) and ascorbic acid (ASC) in methotrexate (MTX) …

Methotrexate (MTX), a chemotherapeutic and immunosuppressant drug, is generally well-
tolerated by most patients. However, its cytotoxic nature contributes to life-threatening side …

Abstract Phosphine (PH3), from hydrolysis of magnesium, zinc, and aluminum phosphide
(AlP), is a rodenticide and insecticide which is used to avoid losses of the agriculture …

Background Methotrexate (MTX) is used commonly in the treatment of various cancers and
inflammatory diseases; nevertheless, the associated hepatotoxicity has limited its clinical …

Background & Aims Acetaminophen (APAP) overdose is a leading cause of drug-induced
acute liver failure. Prolonged c-Jun N-terminal kinase (JNK) activation plays a central role in …

Systemic lupus erythematosus (SLE) encompass a broad spectrum of liver diseases. We
propose here to classify them as follows:(1) immunological comorbilities (overlap …