Old questions, new models: unraveling complex organ regeneration with new experimental approaches

M Grillo, N Konstantinides, M Averof - Current opinion in genetics & …, 2016 - Elsevier
How do some animals like crabs, flatworms and salamanders regenerate entire body parts
after a severe injury? Which are the mechanisms and how did that regenerative ability …

Evolution and regulation of limb regeneration in arthropods

Y Suzuki, J Chou, SL Garvey, VR Wang… - Evo-devo: Non-model …, 2019 - Springer
Regeneration has fascinated both scientists and non-scientists for centuries. Many
organisms can regenerate, and arthropod limbs are no exception although their ability to …

[HTML][HTML] Two transcriptional cascades orchestrate cockroach leg regeneration

C Ren, Y Wen, S Zheng, Z Zhao, EY Li, C Zhao, M Liao… - Cell reports, 2024 - cell.com
The mystery of appendage regeneration has fascinated humans for centuries, while the
underlying regulatory mechanisms remain unclear. In this study, we establish a …

Toll signalling promotes blastema cell proliferation during cricket leg regeneration via insect macrophages

T Bando, M Okumura, Y Bando, M Hagiwara… - …, 2022 - journals.biologists.com
Hemimetabolous insects, such as the two-spotted cricket Gryllus bimaculatus, can recover
lost tissues, in contrast to the limited regenerative abilities of human tissues. Following …

ERK-activated CK-2 triggers blastema formation during appendage regeneration

XS Zhang, L Wei, W Zhang, FX Zhang, L Li, L Li… - Science …, 2024 - science.org
Appendage regeneration relies on the formation of blastema, a heterogeneous cellular
structure formed at the injury site. However, little is known about the early injury-activated …

Regulatory mechanisms underlying the specification of the pupal-homologous stage in a hemimetabolous insect

Y Ishimaru, S Tomonari… - … of The Royal …, 2019 - royalsocietypublishing.org
Juvenile hormones and the genetic interaction between the transcription factors Krüppel
homologue 1 (Kr-h1) and Broad (Br) regulate the transformation of insects from immature to …

Leg regeneration is epigenetically regulated by histone H3K27 methylation in the cricket Gryllus bimaculatus

Y Hamada, T Bando, T Nakamura, Y Ishimaru… - …, 2015 - journals.biologists.com
Hemimetabolous insects such as the cricket Gryllus bimaculatus regenerate lost tissue parts
using blastemal cells, a population of dedifferentiated proliferating cells. The expression of …

Developmental mechanism of the tarsus in insect legs

T Kojima - Current opinion in insect science, 2017 - Elsevier
Highlights•The number and proportion of tarsal segments are highly variable among insect
species.•Studies in D. melanogaster have revealed many key aspects of tarsal …

[PDF][PDF] Molecular mechanisms of limb regeneration: insights from regenerating legs of the cricket Gryllus bimaculatus

T Bando, T Mito, Y Hamada, Y Ishimaru, S Noji… - Int J Dev …, 2018 - academia.edu
This review summarizes recent advances in leg regeneration research, focusing on the
cricket Gryllus bimaculatus. Recent studies have revealed molecular mechanisms on …

Linking body condition and thermal physiology in limping crickets: Does limb autotomy incur costs concerning behavioral thermal tolerance?

JC Díaz‐Ricaurte, EC Guevara‐Molina… - … Zoology Part A …, 2022 - Wiley Online Library
Many ectotherms have the ability to voluntarily detach a body part, known as autotomy,
usually in response to predator attacks. Autotomy can have an immediate benefit for …