Cancer is now considered a tumor microenvironment (TME) disease, although it was
originally thought to be a cell and gene expression disorder. Over the past 20 years …

Ferroptosis is a novel type of programmed cell death, characterized by a dysregulated iron
metabolism and accumulation of lipid peroxides. It features the alteration of mitochondria …

Inhibition of glycolysis in immune cells and cancer cells diminishes their activity, and thus
combining immunotherapies with glycolytic inhibitors is challenging. Herein, a strategy is …

Tumour cells adapt to nutrient deprivation in vivo, yet strategies targeting the nutrient poor
microenvironment remain unexplored. In melanoma, tumour cells often experience low …

Background: Melanoma is a cancer of the skin with potential to spread to other organs and is
responsible for most deaths due to skin cancer. It is imperative to identify immune …

Cutaneous melanoma (CM) is a highly aggressive and drug resistant solid tumor, showing
an impressive metabolic plasticity modulated by oncogenic activation. In particular …

Cutaneous malignant melanoma (hereafter called melanoma) is one of the most aggressive
cancers with increasing incidence and mortality rates worldwide. In this study, we performed …

Altered metabolism is a hallmark of cancer and glycolysis is one of the important factors
promoting tumor development. There is however still a lack of molecular characterization …

Cutaneous melanoma (CM) represents one of the most metastasizing and drug resistant
solid tumors. CM is characterized by a remarkable metabolic plasticity and an important …

Over the past decades, melanoma-related mortality has remained nearly stable. The main
reason is treatment failure of metastatic disease and the inherently linked knowledge gap …