Transforming growth factor-β (TGF-β) represents an evolutionarily conserved family of
secreted polypeptide factors that regulate many aspects of physiological embryogenesis …

Encoded in mammalian cells by 33 genes, the transforming growth factor–β (TGF-β) family
of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Arthrofibrosis is a fibrotic joint disorder that begins with an inflammatory reaction to insults
such as injury, surgery and infection. Excessive extracellular matrix and adhesions contract …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. During
the past decade, novel pathogenic mechanisms of IPF have been elucidated that have …

Although therapeutic targets have been developed for colorectal cancer (CRC) therapy, the
therapeutic effects are not ideal and the survival rate for CRC patients remains poor …

Transforming growth factor beta (TGF-β) is a multi-functional polypeptide that plays a critical
role in regulating a broad range of cellular functions and physiological processes. Signaling …

Protein methyltransferases have been shown to methylate histone and non-histone proteins,
leading to regulation of several biological processes that control cell homeostasis. Over the …

Background: The immunotherapy sensitivity of patients with bladder cancer (BCa) remains
low. As the role of protein methylation in tumorigenesis and development becomes clearer …

Landmark discoveries made nearly two decades ago identified known transcriptional
regulators as histone lysine methyltransferases. Since then, the field of lysine methylation …