Immune effector cells, including cytotoxic T cells (CTLs), induce apoptosis and eliminate
target cells by direct cell–cell contacts. In vivo, CTLs fail to efficiently kill solid tumor cells by …

Regulated cell death (RCD) controls the removal of dispensable, infected or malignant cells,
and is thus essential for development, homeostasis and immunity of multicellular organisms …

A paradigm shift in the study of cell death is currently occurring: whereas previously we had
always considered that there were" points of no return" in any cell death pathway, we now …

Micronuclei are DNA-containing structures separate from the nucleus found in cancer cells.
Micronuclei are recognized by the immune sensor axis cGAS/STING, driving cancer …

During life, the DNA of our cells is continuously exposed to external damaging processes.
Despite the activity of various repair mechanisms, DNA damage eventually results in the …

The mitochondrial apoptosis pathway has the function to kill the cell, but recent work shows
that this pathway can also be activated to a sublethal level, where signal transduction can be …

For decades, we have assumed that all regulated cell death pathways have a dedicated
“point of no return” that precedes death but after which cells are committed to die. The …

Objectives: Investigating haloperidol's cytogenetic behavior in cultured human T
lymphocytes of patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis …

Objectives: This study will investigate olanzapine's cytogenetic behavior in cultured human T
lymphocytes in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis …

Canine insulinoma is a malignant and metastatic tumor of the endocrine pancreas. Clinical
evidence suggests that toceranib phosphate (Palladia), a small molecule receptor tyrosine …