Immunology of leprosy
LAR Froes Jr, MAB Trindade… - International Reviews of …, 2022 - Taylor & Francis
Leprosy is a disease caused by Mycobacterium leprae (ML) with diverse clinical
manifestations, which are strongly correlated with the host's immune response. Skin lesions …
manifestations, which are strongly correlated with the host's immune response. Skin lesions …
Challenges and advances in serological and molecular tests to aid leprosy diagnosis
L Lopes-Luz, DP Saavedra… - Experimental …, 2023 - journals.sagepub.com
Leprosy is a neglected chronic infectious disease caused by obligate intracellular bacilli,
Mycobacterium leprae and Mycobacterium lepromatosis. Despite multidrug therapy (MDT) …
Mycobacterium leprae and Mycobacterium lepromatosis. Despite multidrug therapy (MDT) …
[HTML][HTML] Unexpectedly high leprosy seroprevalence detected using a random surveillance strategy in midwestern Brazil: A comparison of ELISA and a rapid diagnostic …
Background Leprosy diagnosis is mainly based on clinical evaluation, although this
approach is difficult, especially for untrained physicians. We conducted a temporary …
approach is difficult, especially for untrained physicians. We conducted a temporary …
Rapid quantitative serological test for detection of infection with Mycobacterium leprae, the causative agent of leprosy
MS Duthie, MF Balagon, A Maghanoy… - Journal of clinical …, 2014 - Am Soc Microbiol
Leprosy remains an important health problem in a number of regions. Early detection of
infection, followed by effective treatment, is critical to reduce disease progression. New …
infection, followed by effective treatment, is critical to reduce disease progression. New …
[HTML][HTML] Accuracy of rapid point-of-care serological tests for leprosy diagnosis: a systematic review and meta-analysis
CP Romero, R Castro, PEA do Brasil… - Memórias do Instituto …, 2022 - SciELO Brasil
BACKGROUND Leprosy is a chronic infectious disease, still endemic in many countries that
may lead to neurological, ophthalmic, and motor sequelae if not treated early. Access to …
may lead to neurological, ophthalmic, and motor sequelae if not treated early. Access to …
[HTML][HTML] NDO-BSA, LID-1, and NDO-LID antibody responses for infection and RLEP by quantitative PCR as a confirmatory test for early leprosy diagnosis
AR Gobbo, RC Bouth, TMP Moraes, P Pinto… - Frontiers in Tropical …, 2022 - frontiersin.org
Diagnostic tests for leprosy are limited, especially to identify early leprosy cases. We
performed active case findings of leprosy to validate three potential antigen candidates and …
performed active case findings of leprosy to validate three potential antigen candidates and …
Specific IgG antibody responses may be used to monitor leprosy treatment efficacy and as recurrence prognostic markers
MS Duthie, MN Hay, EM Rada, J Convit, L Ito… - European Journal of …, 2011 - Springer
Although curable, leprosy requires better diagnostic and prognostic tools to accompany
therapeutic strategies. We evaluated the serum samples of leprosy patients from Venezuela …
therapeutic strategies. We evaluated the serum samples of leprosy patients from Venezuela …
Insight toward Early Diagnosis of Leprosy through Analysis of the Developing Antibody Responses of Mycobacterium leprae-Infected Armadillos
MS Duthie, RW Truman, W Goto… - Clinical and vaccine …, 2011 - Am Soc Microbiol
Leprosy is a debilitating chronic disease caused by infection with Mycobacterium leprae. A
World Health Organization-directed control strategy based upon the identification and …
World Health Organization-directed control strategy based upon the identification and …
[HTML][HTML] Recent laboratory advances in diagnostics and monitoring response to treatment in leprosy
U Sengupta - Indian Dermatology Online Journal, 2019 - journals.lww.com
The present review briefly summarizes the highlights of the recent advances in
Mycobacterium leprae-specific tests for early diagnosis of leprosy. In addition to establishing …
Mycobacterium leprae-specific tests for early diagnosis of leprosy. In addition to establishing …
Rational design and evaluation of a multiepitope chimeric fusion protein with the potential for leprosy diagnosis
MS Duthie, MN Hay, CZ Morales, L Carter… - Clinical and Vaccine …, 2010 - Am Soc Microbiol
Despite the reduction in the number of leprosy cases registered worldwide as a result of the
widespread use of multidrug therapy, the number of new cases detected each year remains …
widespread use of multidrug therapy, the number of new cases detected each year remains …