Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …

Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in
diverse biological processes, including different aspects of immune functions. Ubiquitination …

Nucleotide binding oligomerization domain (NOD)-like receptors are cytoplasmic pattern-
recognition receptors that together with RIG-I-like receptor (retinoic acid-inducible gene 1) …

A major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat
containing, or NOD-like receptor) proteins is in inflammasome activation, which has been …

Nucleotide-binding and oligomerization domain NOD-like receptors (NLRs) are highly
conserved cytosolic pattern recognition receptors that perform critical functions in surveying …

Cancer cells develop under immune surveillance, thus necessitating immune escape for
successful growth. Loss of MHC class I expression provides a key immune evasion strategy …

The expression of MHC class I molecules is crucial for the initiation and regulation of
adaptive immune responses against pathogens. NOD-, LRR-and CARD-containing 5 …

Summary cGAS-STING signaling is essential for innate immunity. Its misregulation promotes
cancer or autoimmune and autoinflammatory diseases, and it is imperative to identify …

Diabetic kidney disease (DKD) is a major cause of chronic kidney disease (CKD) in many
developed and developing countries. Pyroptosis is a recently discovered form of …