The focus of this review is to provide an overview of the current state of knowledge of
molecular mechanisms/processes that control differentiation of vascular smooth muscle cells …

The vessel wall is an active, integrated organ composed of endothelial, smooth-muscle, and
fibroblast cells coupled to each other in a complex autocrine-paracrine set of interactions …

Perspectives Page 1 Perspectives Transforming Growth Factor-,B in Disease: The Dark Side of
Tissue Repair Wayne A. Border* and Erkki Ruoslahtit *Division ofNephrology, University …

Repair of arterial injury produced by balloon angioplasty leads to the formation of a
neointima and a narrowing of the vascular lumen. In this study, we examined the possibility …

Age-related progression of cardiovascular disease is by far the largest health problem in the
US and involves vascular damage, progressive vascular fibrosis and the accumulation of …

Elevated blood pressure imposes increased mechanical stress on the vascular wall, and
mechanical strain is a mitogenic stimulus for vascular smooth muscle (VSM) cells. The role …

Angiotensin (Ang) II stimulates hypertrophic growth of vascular smooth muscle cells (VSMC).
Accompanying this growth is the induction of the expression of growth-related …

Vascular fibrosis, characterized by reduced lumen diameter and arterial wall thickening
attributable to excessive deposition of extracellular matrix (ECM), links with many clinical …

The purpose of this study was to evaluate the vasoformative response of isolated vascular
explants to a variety of growth factors that have been shown to stimulate angiogenesis …

A dysregulation of the renin-angiotensin system (RAS) has been involved in the genesis of
lung injury and acute respiratory distress syndrome from different causes, including several …