Regulation of stem cells in adult tissues is a key determinant of how well an organism can
respond to the stresses of physiological challenge and disease. This is particularly true of …

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by increased
bleeding tendency and thrombocytopenia. In fact, the precise pathogenesis of this disease is …

Megakaryocytes are rare cells found in the bone marrow, responsible for the everyday
production and release of millions of platelets into the bloodstream. Since the discovery and …

Hematopoietic stem (HSC) and progenitor (HPC) cell fate is governed by intrinsic and
extrinsic parameters. We examined the impact of hematopoietic niche elements on HSC and …

Background—Connexins are a widespread family of membrane proteins that assemble into
hexameric hemichannels, also known as connexons. Connexons regulate membrane …

It is nowadays well established that gap junctions are critical gatekeepers of cell
proliferation, by controlling the intercellular exchange of essential growth regulators. In …

Rationale: The hematopoietic system and skeletal system have a close relationship, and
megakaryocytes (MKs) may be involved in maintaining bone homeostasis. However, the …

Mounting evidence indicates that dysregulation of gap junctions and their structural subunits—
connexins—often occurs in, and sometimes causes, a variety of proliferative disorders …

Recent data suggest that megakaryocytes (MKs) play a role in skeletal homeostasis. In vitro
and in vivo data show that MKs stimulate osteoblast (OB) proliferation and inhibit osteoclast …

The concept of the haematopoietic stem cell (HSC) niche was formulated by Schofield in the
1970s, as a region within the bone marrow containing functional cell types that can maintain …