Phase‐shift, stimuli‐responsive perfluorocarbon nanodroplets for drug delivery to cancer

N Rapoport - Wiley Interdisciplinary Reviews: Nanomedicine …, 2012 - Wiley Online Library
This review focuses on phase‐shift perfluorocarbon nanoemulsions whose action depends
on an ultrasound‐triggered phase shift from a liquid to gas state. For drug‐loaded …

Ultrasound-responsive droplets for therapy: A review

H Lea-Banks, MA O'reilly, K Hynynen - Journal of Controlled Release, 2019 - Elsevier
The last two decades have seen the development of acoustically activated droplets, also
known as phase-change emulsions, from a diagnostic tool to a therapeutic agent. Through …

Doxorubicin as a molecular nanotheranostic agent: effect of doxorubicin encapsulation in micelles or nanoemulsions on the ultrasound-mediated intracellular delivery …

P Mohan, N Rapoport - Molecular pharmaceutics, 2010 - ACS Publications
Doxorubicin (DOX) is one of the most commonly used chemotherapeutic drugs and is a
popular research tool due to the inherent fluorescence of the DOX molecule. After DOX …

Formulation and acoustic studies of a new phase-shift agent for diagnostic and therapeutic ultrasound

PS Sheeran, S Luois, PA Dayton, TO Matsunaga - Langmuir, 2011 - ACS Publications
Recent efforts in the area of acoustic droplet vaporization with the objective of designing
extravascular ultrasound contrast agents has led to the development of stabilized, lipid …

Phase-change contrast agents for imaging and therapy

PS Sheeran, PA Dayton - Current pharmaceutical design, 2012 - ingentaconnect.com
Phase-change contrast agents (PCCAs) for ultrasound-based applications have resulted in
novel ways of approaching diagnostic and therapeutic techniques beyond what is possible …

Decafluorobutane as a phase-change contrast agent for low-energy extravascular ultrasonic imaging

PS Sheeran, VP Wong, S Luois, RJ McFarland… - Ultrasound in medicine …, 2011 - Elsevier
Currently available microbubbles used for ultrasound imaging and therapeutics are limited
to intravascular space due to their size distribution in the micron range. Phase-change …

Acoustic droplet vaporization is initiated by superharmonic focusing

O Shpak, M Verweij, HJ Vos… - Proceedings of the …, 2014 - National Acad Sciences
Acoustically sensitive emulsion droplets composed of a liquid perfluorocarbon have the
potential to be a highly efficient system for local drug delivery, embolotherapy, or for tumor …

The role of inertial cavitation in acoustic droplet vaporization

ML Fabiilli, KJ Haworth, NH Fakhri… - IEEE transactions on …, 2009 - ieeexplore.ieee.org
The vaporization of a superheated droplet emulsion into gas bubbles using ultrasound-
termed acoustic droplet vaporization (ADV)-has potential therapeutic applications in …

Characterization of submicron phase-change perfluorocarbon droplets for extravascular ultrasound imaging of cancer

R Williams, C Wright, E Cherin, N Reznik, M Lee… - Ultrasound in medicine …, 2013 - Elsevier
Because many tumors possess blood vessels permeable to particles with diameters of 200
nm, it is possible that submicron perfluorocarbon droplets could constitute a novel …

Delivery of chlorambucil using an acoustically-triggered perfluoropentane emulsion

ML Fabiilli, KJ Haworth, IE Sebastian… - Ultrasound in medicine …, 2010 - Elsevier
Ultrasound-mediated delivery systems have mainly focused on microbubble contrast agents
as carriers of drugs or genetic material. This study uses micron-sized, perfluoropentane …