Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence
has increased globally since the 1970s, and the number of obese and overweight people is …

Classically, the following three morphological states of microglia have been defined:
ramified, amoeboid and phagocytic. While ramified cells were long regarded as “resting” …

Newborn microglia rapidly replenish the whole brain after selective elimination of most
microglia (> 99%) in adult mice. Previous studies reported that repopulated microglia were …

Microglia, resident macrophages of the CNS, are essential to brain development,
homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS …

Injury is a key driver of inflammation, a critical yet necessary response involving several
mediators that is aimed at restoring tissue homeostasis. Inflammation in the central nervous …

Immune cells react to their environment by flexibly reprogramming intracellular metabolic
pathways that subsequently alter immune function, in a process called immunometabolism …

Obesity is a global health problem with a broad set of comorbidities, such as malnutrition,
metabolic syndrome, diabetes, systemic hypertension, heart failure, and kidney failure. This …

Diabetes mellitus is a heterogeneous chronic metabolic disorder characterized by the
presence of hyperglycemia, commonly preceded by a prediabetic state. The excess of blood …

Astrocytes, microglia, and tanycytes play active roles in the regulation of hypothalamic
feeding circuits. These non-neuronal cells are crucial in determining the functional …

Neuropsychological deficits, including impairments in learning and memory, occur after
spinal cord injury (SCI). In experimental SCI models, we and others have reported that such …