This paper is the thirty-seventh consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2014 …

Background Individual differences in the subjective experience of the pharmacological
effects of alcohol have long been implicated in the likelihood that one will drink heavily and …

Importance Alcohol use disorder is one of the leading causes of disability worldwide. While
effective pharmacological treatments exist, they are efficacious only in certain individuals …

Background Annually, the use and abuse of alcohol contributes to millions of deaths and
billions of dollars in societal costs. To determine the impact of genetic variation on the …

Understanding factors that contribute to the escalation of alcohol consumption is key to
understanding how an individual transitions from non/social drinking to AUD and to …

Aims This study used a behavioral approach‐avoidance task including images of alcoholic
beverages to test whether low sensitivity to alcohol (LS) is a phenotypical marker of a …

Mu opioid receptors (MORs) are widely distributed throughout brain reward circuits and their
role in drug and social reward is well established. Substantial evidence has implicated MOR …

Background It has been proposed that therapeutic responses to naltrexone in alcoholism
are moderated by variation at the mu-opioid receptor gene locus (OPRM1). This remains …

The placebo effect is a phenomenon in which patients who are given an inactive treatment
(eg, inert pill) show a perceived or actual improvement in a medical condition. Placebo …

Increased consumption of highly processed foods may result in lower diet quality, and low
diet quality is associated with elevated risk of cardiovascular disease, type 2 diabetes, and …