Expansion microscopy of apicomplexan parasites

B Liffner, S Absalon - Molecular Microbiology, 2024 - Wiley Online Library
Apicomplexan parasites comprise significant pathogens of humans, livestock and wildlife,
but also represent a diverse group of eukaryotes with interesting and unique cell biology …

Cytoskeleton Organization in Formation and Motility of Apicomplexan Parasites

RG Douglas, RW Moon… - Annual Review of …, 2024 - annualreviews.org
Apicomplexan parasites are a group of eukaryotic protozoans with diverse biology that have
affected human health like no other group of parasites. These obligate intracellular parasites …

Plasmodium ARK2 and EB1 drive unconventional spindle dynamics, during chromosome segregation in sexual transmission stages

M Zeeshan, E Rea, S Abel, K Vukušić, R Markus… - Nature …, 2023 - nature.com
The Aurora family of kinases orchestrates chromosome segregation and cytokinesis during
cell division, with precise spatiotemporal regulation of its catalytic activities by distinct protein …

Disruption of Plasmodium falciparum kinetochore proteins destabilises the nexus between the centrosome equivalent and the mitotic apparatus

J Li, GJ Shami, B Liffner, E Cho, F Braet… - Nature …, 2024 - nature.com
Plasmodium falciparum is the causative agent of malaria and remains a pathogen of global
importance. Asexual blood stage replication, via a process called schizogony, is an …

Plasmodium microtubule-binding protein EB1 is critical for partitioning of nuclei in male gametogenesis

S Mauer, N Camargo, BA Abatiyow, OR Gargaro… - Mbio, 2023 - Am Soc Microbiol
Sexual reproduction of the malaria parasites is critical for their transmission to a mosquito
vector. Several signaling molecules, such as kinases and phosphatases, are known to …

The three Plasmodium falciparum Aurora-related kinases display distinct temporal and spatial associations with mitotic structures in asexual blood stage parasites …

M Wyss, BT Thommen, J Kofler, E Carrington… - Msphere, 2024 - journals.asm.org
Aurora kinases are crucial regulators of mitotic cell cycle progression in eukaryotes. The
protozoan malaria parasite Plasmodium falciparum replicates via schizogony, a specialized …

The molecular mechanisms driving Plasmodium cell division

DS Guttery, M Zeeshan, AA Holder… - Biochemical Society …, 2024 - portlandpress.com
Malaria, a vector borne disease, is a major global health and socioeconomic problem
caused by the apicomplexan protozoan parasite Plasmodium. The parasite alternates …

A non-canonical Arp2/3 complex is essential for Plasmodium DNA segregation and transmission of malaria.

F Hentzschel, D Jewanski, Y Sokolowski, P Agarwal… - bioRxiv, 2023 - biorxiv.org
The malaria-causing parasite Plasmodium has a complex life cycle involving both vertebrate
and mosquito hosts. Sexual stages or gametocytes are the only stage competent for …

Plasmodium falciparum kinetochore proteins stabilise a nexus between the mitotic apparatus and the apical complex

L Tilley, J Li, G Shami, E Cho, B Liffner, F Braet… - 2023 - researchsquare.com
Plasmodium falciparum is the causative agent of malaria and remains a pathogen of global
importance. Asexual blood stage replication, via a process called schizogony, is an …

Roles of the tubulin-based cytoskeleton in the Toxoplasma gondii apical complex

AT i Puig, D Soldati-Favre - Trends in Parasitology, 2024 - cell.com
Microtubules (MTs) play a vital role as key components of the eukaryotic cytoskeleton. The
phylum Apicomplexa comprises eukaryotic unicellular parasitic organisms defined by the …