Autophagy in liver diseases: a review

H Qian, X Chao, J Williams, S Fulte, T Li, L Yang… - Molecular aspects of …, 2021 - Elsevier
The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

[HTML][HTML] The AMPK pathway in fatty liver disease

C Fang, J Pan, N Qu, Y Lei, J Han, J Zhang… - Frontiers in …, 2022 - frontiersin.org
Lipid metabolism disorders are the primary causes for the occurrence and progression of
various liver diseases, including non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty …

[HTML][HTML] Cell death in liver diseases: a review

L Shojaie, A Iorga, L Dara - International journal of molecular sciences, 2020 - mdpi.com
Regulated cell death (RCD) is pivotal in directing the severity and outcome of liver injury.
Hepatocyte cell death is a critical event in the progression of liver disease due to resultant …

[HTML][HTML] Alcoholic liver disease: pathogenesis and current management

NA Osna, TM Donohue Jr… - Alcohol research: current …, 2017 - ncbi.nlm.nih.gov
Excessive alcohol consumption is a global healthcare problem. The liver sustains the
greatest degree of tissue injury by heavy drinking because it is the primary site of ethanol …

[HTML][HTML] Immunological mechanisms and therapeutic targets of fatty liver diseases

H Wang, W Mehal, LE Nagy, Y Rotman - Cellular & Molecular …, 2021 - nature.com
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …

Impaired TFEB-mediated lysosome biogenesis and autophagy promote chronic ethanol-induced liver injury and steatosis in mice

X Chao, S Wang, K Zhao, Y Li, JA Williams, T Li… - Gastroenterology, 2018 - Elsevier
Background & Aims Defects in lysosome function and autophagy contribute to the
pathogenesis of alcoholic liver disease. We investigated the mechanisms by which alcohol …

Lytic cell death in metabolic liver disease

J Gautheron, GJ Gores, CMP Rodrigues - Journal of hepatology, 2020 - Elsevier
Regulated cell death is intrinsically associated with inflammatory liver disease and is pivotal
in governing outcomes of metabolic liver disease. Different types of cell death may coexist …

Alcoholic liver disease

HK Seitz, R Bataller, H Cortez-Pinto, B Gao… - Nature reviews Disease …, 2018 - nature.com
Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide.
ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is …

[HTML][HTML] Alcohol-associated liver disease: A review on its pathophysiology, diagnosis and drug therapy

V Subramaniyan, S Chakravarthi, R Jegasothy… - Toxicology reports, 2021 - Elsevier
One of the global burdens of health care is an alcohol-associated liver disease (ALD) and
liver-related death which is caused due to acute or chronic consumption of alcohol. Chronic …

[HTML][HTML] Alcohol-related liver disease: basic mechanisms and clinical perspectives

SY Liu, IT Tsai, YC Hsu - International journal of molecular sciences, 2021 - mdpi.com
Alcohol-related liver disease (ALD) refers to the liver damage occurring due to excessive
alcohol consumption and involves a broad spectrum of diseases that includes liver steatosis …