Skeletal muscle damaged by injury or by degenerative diseases such as muscular
dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon …

Satellite cells are tissue resident muscle stem cells required for postnatal skeletal muscle
growth and repair through replacement of damaged myofibers. Muscle regeneration is …

Duchenne muscular dystrophy (DMD) is a severe, progressive muscle disease caused by
mutations in the dystrophin gene. The majority of DMD mutations are deletions that …

Biologic scaffolds composed of naturally occurring extracellular matrix (ECM) can provide a
microenvironmental niche that alters the default healing response toward a constructive and …

As we enter the new millennium, the prospects for the field of Biomedical Engineering are
bright. Individuals interested in pursuing careers in this field continue to increase and the …

Progress toward finding a cure for muscle diseases has been slow because of the absence
of relevant cellular models and the lack of a reliable source of muscle progenitors for …

A major obstacle in the application of cell-based therapies for the treatment of
neuromuscular disorders is obtaining the appropriate number of stem/progenitor cells to …

BACKGROUND Decades of laboratory and clinical investigation have led to successful
therapies using hematopoietic stem cells (HSCs), but few other cell therapies have …

Three populations of myogenic cells were isolated from normal mouse skeletal muscle
based on their adhesion characteristics and proliferation behaviors. Although two of these …

Satellite cells are dormant progenitors located at the periphery of skeletal myofibers that can
be triggered to proliferate for both self-renewal and differentiation into myogenic cells. In …