While the tumor suppressor functions of p53 have long been recognized, the contribution of
p53 to numerous other aspects of disease and normal life is only now being appreciated …

The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …

Targeting the androgen receptor (AR) signaling axis has been, over decades, the mainstay
of prostate cancer therapy. More potent inhibitors of androgen synthesis and antiandrogens …

Abstract p16INK4a, located on chromosome 9p21. 3, is lost among a cluster of neighboring
tumor suppressor genes. Although it is classically known for its capacity to inhibit cyclin …

Purpose EZH2 is a member of the polycomb group of genes and important in cell cycle
regulation. Increased expression of EZH2 has been associated previously with invasive …

The p16INK4A and p14ARF proteins, encoded by the INK4A-ARF locus, are key regulators
of cellular senescence, yet the mechanisms triggering their up-regulation are not well …

Abstract The Polycomb group (PcG) protein Enhancer of Zeste Homolog 2 (EZH2) is one of
the three core subunits of the Polycomb Repressive Complex 2 (PRC2). It harbors histone …

Cell competition was originally described in Drosophila as a process for selection of the
fittest cells. It is likely to play an important role in tissue homeostasis in all metazoans, but …

The molecular mechanism responsible for a decline of stem cell functioning after replicative
stress remains unknown. We used mouse embryonic fibroblasts (MEFs) and hematopoietic …

Cell cycle arrest in response to DNA damage is an important antitumorigenic mechanism.
MicroRNAs (miRNAs) were recently shown to play key regulatory roles in cell cycle …