Inhibition of glycolysis and glutaminolysis: an emerging drug discovery approach to combat cancer
Cancer cells have a very different metabolism from that of normal cells from which they are
derived. Their metabolism is elevated, which allows them to sustain higher proliferative rate …
derived. Their metabolism is elevated, which allows them to sustain higher proliferative rate …
Biochemical basis of anti-cancer-effects of phloretin—A natural dihydrochalcone
BY Choi - Molecules, 2019 - mdpi.com
Apple is a rich source of bioactive phytochemicals that help improve health by preventing
and/or curing many disease processes, including cancer. One of the apple polyphenols is …
and/or curing many disease processes, including cancer. One of the apple polyphenols is …
A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo
The functional and therapeutic importance of the Warburg effect is increasingly recognized,
and glycolysis has become a target of anticancer strategies. We recently reported the …
and glycolysis has become a target of anticancer strategies. We recently reported the …
[HTML][HTML] A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models
C Xintaropoulou, C Ward, A Wise, H Marston… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Many cancer cells rely on aerobic glycolysis for energy production and targeting of this
pathway is a potential strategy to inhibit cancer cell growth. In this study, inhibition of five …
pathway is a potential strategy to inhibit cancer cell growth. In this study, inhibition of five …
Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages
WT Chang, WC Huang, CJ Liou - Food chemistry, 2012 - Elsevier
Many reports suggest that phloretin and phlorizin have antioxidant properties and can inhibit
glucose transportation, the anti-inflammatory effects and mechanism of phloretin and …
glucose transportation, the anti-inflammatory effects and mechanism of phloretin and …
[HTML][HTML] The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter
Human triple-negative breast cancer (TNBC) is the most aggressive and poorly understood
subclass of breast cancer. Glucose transporters (GLUTs) are required for glucose uptake in …
subclass of breast cancer. Glucose transporters (GLUTs) are required for glucose uptake in …
Dermatological applications of the flavonoid phloretin
TPA Casarini, LA Frank, AR Pohlmann… - European journal of …, 2020 - Elsevier
Botanical molecules are known to have the ability to counteract ultraviolet radiation-induced
skin damage. The interest in the development of natural compound-based products for the …
skin damage. The interest in the development of natural compound-based products for the …
[HTML][HTML] Cancer cell metabolism: Rewiring the mitochondrial hub
To adapt to tumoral environment conditions or even to escape chemotherapy, cells rapidly
reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies …
reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies …
Cancer: fundamentals behind pH targeting and the double-edged approach
T Koltai - OncoTargets and therapy, 2016 - Taylor & Francis
The highly regulated pH of cells and the less-regulated pH of the surrounding extracellular
matrix (ECM) is the result of a delicate balance between metabolic processes and proton …
matrix (ECM) is the result of a delicate balance between metabolic processes and proton …
Apple phenolics as nutraceuticals: assessment, analysis and application
S Rana, S Bhushan - Journal of food science and technology, 2016 - Springer
Humankind is presently engulfed by convenience quench, modern life style and urbanized
diet system leading to progression in array of health disorders. The past decade confronted …
diet system leading to progression in array of health disorders. The past decade confronted …