Inhibition of glycolysis and glutaminolysis: an emerging drug discovery approach to combat cancer

NS Akins, TC Nielson, HV Le - Current topics in medicinal …, 2018 - ingentaconnect.com
Cancer cells have a very different metabolism from that of normal cells from which they are
derived. Their metabolism is elevated, which allows them to sustain higher proliferative rate …

Biochemical basis of anti-cancer-effects of phloretin—A natural dihydrochalcone

BY Choi - Molecules, 2019 - mdpi.com
Apple is a rich source of bioactive phytochemicals that help improve health by preventing
and/or curing many disease processes, including cancer. One of the apple polyphenols is …

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

Y Liu, Y Cao, W Zhang, S Bergmeier, Y Qian… - Molecular cancer …, 2012 - AACR
The functional and therapeutic importance of the Warburg effect is increasingly recognized,
and glycolysis has become a target of anticancer strategies. We recently reported the …

[HTML][HTML] A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models

C Xintaropoulou, C Ward, A Wise, H Marston… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Many cancer cells rely on aerobic glycolysis for energy production and targeting of this
pathway is a potential strategy to inhibit cancer cell growth. In this study, inhibition of five …

Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages

WT Chang, WC Huang, CJ Liou - Food chemistry, 2012 - Elsevier
Many reports suggest that phloretin and phlorizin have antioxidant properties and can inhibit
glucose transportation, the anti-inflammatory effects and mechanism of phloretin and …

[HTML][HTML] The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter

KH Wu, CT Ho, ZF Chen, LC Chen… - journal of food and drug …, 2018 - Elsevier
Human triple-negative breast cancer (TNBC) is the most aggressive and poorly understood
subclass of breast cancer. Glucose transporters (GLUTs) are required for glucose uptake in …

Dermatological applications of the flavonoid phloretin

TPA Casarini, LA Frank, AR Pohlmann… - European journal of …, 2020 - Elsevier
Botanical molecules are known to have the ability to counteract ultraviolet radiation-induced
skin damage. The interest in the development of natural compound-based products for the …

[HTML][HTML] Cancer cell metabolism: Rewiring the mitochondrial hub

GL Oliveira, AR Coelho, R Marques… - Biochimica et Biophysica …, 2021 - Elsevier
To adapt to tumoral environment conditions or even to escape chemotherapy, cells rapidly
reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies …

Cancer: fundamentals behind pH targeting and the double-edged approach

T Koltai - OncoTargets and therapy, 2016 - Taylor & Francis
The highly regulated pH of cells and the less-regulated pH of the surrounding extracellular
matrix (ECM) is the result of a delicate balance between metabolic processes and proton …

Apple phenolics as nutraceuticals: assessment, analysis and application

S Rana, S Bhushan - Journal of food science and technology, 2016 - Springer
Humankind is presently engulfed by convenience quench, modern life style and urbanized
diet system leading to progression in array of health disorders. The past decade confronted …