The impact of systemic inflammation on Alzheimer's disease pathology

J Xie, L Van Hoecke, RE Vandenbroucke - Frontiers in immunology, 2022 - frontiersin.org
Alzheimer's disease (AD) is a devastating age-related neurodegenerative disorder with an
alarming increasing prevalence. Except for the recently FDA-approved Aducanumab of …

Lipopolysaccharide-induced neuroinflammation as a bridge to understand neurodegeneration

CRA Batista, GF Gomes, E Candelario-Jalil… - International journal of …, 2019 - mdpi.com
A large body of experimental evidence suggests that neuroinflammation is a key
pathological event triggering and perpetuating the neurodegenerative process associated …

Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential

X Ding, L Gao, Z Han, S Eleuteri, W Shi, Y Shen… - Ageing research …, 2023 - Elsevier
Parkinson's Disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …

Alzheimer's disease: etiology, neuropathology and pathogenesis

O Sheppard, M Coleman - Exon Publications, 2020 - exonpublications.com
Alzheimer's disease is the most common form of dementia and the most common
neurodegenerative disease. It manifests as a decline in short-term memory and cognition …

Gram-negative bacteria and their lipopolysaccharides in Alzheimer's disease: pathologic roles and therapeutic implications

H Kim, S Kim, SJ Shin, YH Park, Y Nam, C Kim… - Translational …, 2021 - Springer
Alzheimer's disease (AD) is the most serious age-related neurodegenerative disease and
causes destructive and irreversible cognitive decline. Failures in the development of …

A peripheral signature of Alzheimer's disease featuring microbiota-gut-brain axis markers

M Marizzoni, P Mirabelli, E Mombelli, L Coppola… - Alzheimer's Research & …, 2023 - Springer
Background Increasing evidence links the gut microbiota (GM) to Alzheimer's disease (AD)
but the mechanisms through which gut bacteria influence the brain are still unclear. This …

The neurobiology and therapeutic potential of multi-targeting β-secretase, glycogen synthase kinase 3β and acetylcholinesterase in Alzheimer's disease

MG Fronza, D Alves, D Praticò, L Savegnago - Ageing research reviews, 2023 - Elsevier
Alzheimer's Disease (AD) is the most common form of dementia, affecting almost 50 million
of people around the world, characterized by a complex and age-related progressive …

Animal models of Parkinson's disease: bridging the gap between disease hallmarks and research questions

A Dovonou, C Bolduc, V Soto Linan, C Gora… - Translational …, 2023 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …

Inflammation in neurological disorders: the thin boundary between brain and periphery

C Cervellati, A Trentini, A Pecorelli… - Antioxidants & Redox …, 2020 - liebertpub.com
Significance: Accumulating evidence suggests that inflammation is a major contributor in the
pathogenesis of several highly prevalent, but also rare, neurological diseases. In particular …

Systemic infection exacerbates cerebrovascular dysfunction in Alzheimer's disease

D Asby, D Boche, S Allan, S Love, JS Miners - Brain, 2021 - academic.oup.com
We studied the effects of systemic infection on brain cytokine level and cerebral vascular
function in Alzheimer's disease and vascular dementia, in superior temporal cortex …