Nitrogen heterocycles play an essential role in medication development. The 1, 2, 4‐
oxadiazole heterocycle has been extensively studied, yielding a large variety of molecules …

Quinazoline heterocycles are critical in the development of medications. Quinazoline
derivatives have been intensively researched, providing a wide range of compounds with …

Fragment merging approach was applied for the design of thiazole/thiazolidinone clubbed
pyrazoline derivatives 5a-e, 6a-c, 7 and 10a-d as dual COX-2 and 5-LOX inhibitors …

In an attempt to obtain new candidates with potential anti-inflammatory activity, two series of
1, 3, 4-oxadiazole based derivatives (8a–g) and 1, 2, 4-triazole based derivatives (10a, b …

Microglia-mediated neuroinflammation plays an important role in ischemic stroke (IS). In this
work, a series of novel indole and indazole-piperazine pyrimidine derivatives with anti …

Currently, selective COX-2 inhibitors are used as a novel alternative approach in the course
of pain management due to their reduced adverse that generally occur after COX-1 …

A new series of 1, 2, 3-triazole derivatives 5a–f based on benzothiazole were synthesized by
the 1, 3-dipolar cycloaddition reaction of S-propargyl mercaptobenzothiazole and α-halo …

Inflammation is a multifaceted phenomenon triggered by potentially active mediators acutely
released arachidonic acid metabolites partially in lipoxygenase (LOX) pathway which are …

Regarding that the chronic use of commonly available non-steroidal and anti-inflammatory
drugs (NSAIDs) is often restricted by their adverse effects, there is still a current need to …

The study was carried out on 42 male rats divided into six groups with 7 rats in each group:
two control groups, two injury groups and two treatment groups. One of the control groups …