The “fetal” or “early” origins of adult disease hypothesis was originally put forward by David
Barker and colleagues and stated that environmental factors, particularly nutrition, act in …

Experimental studies that are relevant to human pregnancy rely on the selection of
appropriate animal models as an important element in experimental design. Consideration …

The 'developmental origins of adult health and disease'hypothesis stated that environmental
factors, particularly maternal undernutrition, act in early life to programme the risks for …

Abstract Tri-iodo-l-thyronine (T 3) suppresses the proliferation of near-term serum-stimulated
fetal ovine cardiomyocytes in vitro. Thus, we hypothesized that T 3 is a major stimulant of …

Aims Pre-term birth affects 10–12% of live births and occurs when the myocardium is still
developing; therefore, the final structure of the myocardium could be altered. We …

Low blood flow through the fetal left heart is often conjectured as an etiology for hypoplastic
left heart syndrome (HLHS). To investigate if a decrease in left heart flow results in growth …

Highlights•Binucleation and terminal differentiation dictate cardiomyocyte endowment for
life.•Adverse early life events affect cardiomyocyte number in adulthood.•Epigenetic …

Placental insufficiency, resulting in restriction of fetal substrate supply, is a major cause of
intrauterine growth restriction (IUGR) and increased neonatal morbidity. Fetal adaptations to …

The postnatal mammalian heart undergoes remarkable developmental changes, which are
stimulated by the transition from the intrauterine to extrauterine environment. With birth …

Background Placental insufficiency is the leading cause of intrauterine growth restriction in
the developed world and results in chronic hypoxemia in the fetus. Oxygen is essential for …