Maintaining muscle quality throughout life is crucial to human health and well-being. Muscle
is the most extensive form of protein storage in the human body; skeletal muscle mass is …

The mechanistic target of rapamycin complex 1 (mTORC1) kinase controls growth in
response to nutrients, including the amino acid leucine. In cultured cells, mTORC1 senses …

The branched-chain aminotransferase isozymes BCAT1 and BCAT2, segregated into
distinct subcellular compartments and tissues, initiate the catabolism of branched-chain …

ER protein homeostasis (proteostasis) is essential for proper folding and maturation of
proteins in the secretory pathway. Loss of ER proteostasis can lead to the accumulation of …

Mitochondrial dysfunction causes devastating disorders, including mitochondrial myopathy,
but how muscle senses and adapts to mitochondrial dysfunction is not well understood …

The conserved protein kinase mTOR (mechanistic target of rapamycin) responds to diverse
environmental cues to control cell metabolism and promote cell growth, proliferation, and …

Simultaneous inhibition of transforming growth factor‐β (TGF‐β) type I receptors Acvr1b and
Tgfbr1 signalling has been associated with excessive skeletal muscle hypertrophy in vivo …

The cardiomyocyte is the main cell type in the heart responsible for its contractile function.
Culturing primary cardiomyocytes from mammalian sources to study their function remains …

Innovative therapeutic strategies have emerged over the past decade to improve outcomes
for most lymphoma patients. Nevertheless, the aggressive presentation seen in high-risk …

Endoplasmic reticulum (ER) stress is involved in skeletal muscle atrophy in various
conditions, but the role of ER stress in sepsis‐induced muscle atrophy is not well …