Recent advancements in experimental high-throughput technologies have expanded the
availability and quantity of molecular data in biology. Given the importance of interactions in …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

The COVID-19 pandemic has highlighted the need to quickly and reliably prioritize clinically
approved compounds for their potential effectiveness for severe acute respiratory syndrome …

Summary The coronavirus disease 2019 (COVID-19) pandemic is a global public health
crisis. However, little is known about the pathogenesis and biomarkers of COVID-19. Here …

INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders,
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …

A system-wide understanding of cellular function requires knowledge of all functional
interactions between the expressed proteins. The STRING database aims to collect and …

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …

Genome-scale human protein–protein interaction networks are critical to understanding cell
biology and interpreting genomic data, but challenging to produce experimentally. Through …

We describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC).
Using this dataset, we expand the catalogue of known ACC driver genes to include …

Cancers exhibit extensive mutational heterogeneity, and the resulting long-tail phenomenon
complicates the discovery of genes and pathways that are significantly mutated in cancer …