The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …

Inflammation constitutes a complex, highly conserved cascade of molecular and cellular
events. Inflammation has been labeled as “the fire within,” is highly regulated, and is critical …

Cigarette smoking is a major risk factor for atherosclerosis and other cardiovascular
diseases. Increasing evidence has demonstrated that nicotine impairs the cardiovascular …

Atherosclerosis starts early in life and progresses silently for decades. Considering
atherosclerosis as a “systemic disease” invites the use of noninvasive methodologies to …

Background: Atherosclerosis is a chronic inflammatory disease, but data on arterial
inflammation at early stages is limited. Objectives: The purpose of this study was to …

A major challenge in tissue engineering is the generation of sufficient volumes of viable
tissue for organ transplant. The development of a stable, mature vasculature is required to …

Although substantial evidence shows that smoking is positively and robustly associated with
cardiovascular disease (CVD), the CVD risk associated with the use of new and emerging …

To inform the study and regulation of emerging tobacco products, we sought to identify
sensitive biomarkers of tobacco-induced subclinical cardiovascular damage by testing the …

Abstract Purpose of Review Precision Aging® is a novel concept that we have recently
employed to describe how the model of precision medicine can be used to understand and …

Background and aims Proprotein convertase subtilisin/kexin type 9 (PCSK9) is one of the
key regulators of low-density lipoprotein cholesterol plasma levels. Circulating PCSK9 …