Challenges and advances in clinical applications of mesenchymal stromal cells

T Zhou, Z Yuan, J Weng, D Pei, X Du, C He… - Journal of hematology & …, 2021 - Springer
Mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have been
intensely investigated for clinical applications within the last decades. However, the majority …

A decade of progress in tissue engineering

A Khademhosseini, R Langer - Nature protocols, 2016 - nature.com
Tremendous progress has been achieved in the field of tissue engineering in the past
decade. Several major challenges laid down 10 years ago, have been studied, including …

Manufacturing of primed mesenchymal stromal cells for therapy

JQ Yin, J Zhu, JA Ankrum - Nature biomedical engineering, 2019 - nature.com
Mesenchymal stromal cells (MSCs) for basic research and clinical applications are
manufactured and developed as unique cell products by many different manufacturers and …

Peptides as multifunctional players in cancer therapy

SMP Vadevoo, S Gurung, HS Lee… - … & Molecular Medicine, 2023 - nature.com
Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely,
peptides demonstrate higher efficiency in tissue penetration and cell internalization than …

[HTML][HTML] Homing and migration of mesenchymal stromal cells: how to improve the efficacy of cell therapy?

A De Becker, I Van Riet - World journal of stem cells, 2016 - ncbi.nlm.nih.gov
Mesenchymal stromal cells (MSCs) are currently being investigated for use in a wide variety
of clinical applications. For most of these applications, systemic delivery of the cells is …

Concise review: MSC adhesion cascade—insights into homing and transendothelial migration

F Nitzsche, C Müller, B Lukomska, J Jolkkonen… - Stem …, 2017 - academic.oup.com
Mesenchymal stem cells (MSCs) are promising candidates for adult cell therapies in
regenerative medicine. To fully exert their potential, efficient homing and migration toward …

Bone tissue engineering: recent advances and challenges

AR Amini, CT Laurencin… - Critical Reviews™ in …, 2012 - dl.begellhouse.com
The worldwide incidence of bone disorders and conditions has trended steeply upward and
is expected to double by 2020, especially in populations where aging is coupled with …

Concise review: mesenchymal stem cell-based drug delivery: the good, the bad, the ugly, and the promise

TEG Krueger, DLJ Thorek… - Stem cells …, 2018 - academic.oup.com
The development of mesenchymal stem cells (MSCs) as cell-based drug delivery vectors for
numerous clinical indications, including cancer, has significant promise. However, a …

Advances in porous scaffold design for bone and cartilage tissue engineering and regeneration

A Cheng, Z Schwartz, A Kahn, X Li, Z Shao… - … Engineering Part B …, 2019 - liebertpub.com
Tissue engineering of bone and cartilage has progressed from simple to sophisticated
materials with defined porosity, surface features, and the ability to deliver biological factors …

[PDF][PDF] Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease

SH Ranganath, O Levy, MS Inamdar, JM Karp - Cell stem cell, 2012 - cell.com
The broad repertoire of secreted trophic and immunomodulatory cytokines produced by
mesenchymal stem cells (MSCs), generally referred to as the MSC secretome, has …