The fact that exposure to severe stress leads to the development of psychiatric disorders
serves as the basic rationale for animal models of stress disorders. Clinical and …

As the population ages, the economic and societal impacts of neurodegenerative and
neuropsychiatric disorders are expected to rise sharply. Like dementia, late-life depressive …

BACKGROUND: Neuroimaging studies have shown that major depressive disorder (MDD)
is accompanied by structural and functional abnormalities in specific brain regions and …

OBJECTIVE: Several studies have found reduced hippocampal volume in patients with
unipolar depression, but discrepancies exist. The authors performed a systematic review …

Objective: The authors used resting-state functional connectivity MRI to evaluate brain
networks in patients with refractory and nonrefractory major depressive disorder. Method: In …

Background Abnormalities in prefrontal and anterior cingulate cortices are implicated in
disturbances of attention, cognition, and impulse regulation in bipolar disorder. Acute …

It has been proposed that a “depression–executive dysfunction (DED) syndrome” occurs in
late life. This assertion was based on clinical, neuropathological, and neuroimaging findings …

OBJECTIVE: To examine structural abnormalities in subregions of the prefrontal cortex in
elderly patients with depression, the authors explored differences in gray matter, white …

BACKGROUND: Executive dysfunction is common in geriatric depression and persists after
improvement of depressive symptoms. This study examined the relationship of executive …

Mood disorders are common psychiatric illnesses that represent a major cause of disability
and mortality worldwide. It is estimated that 8% to 20% of the population will experience a …