Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

It is increasingly accepted that early cognitive impairment in Alzheimer's disease results in
considerable part from synaptic dysfunction caused by the accumulation of a range of …

Soluble oligomers of amyloid β-protein (oAβ) isolated from the brains of Alzheimer's disease
(AD) patients have been shown experimentally (in the absence of amyloid plaques) to …

Background Human prion diseases, including Creutzfeldt–Jakob disease (CJD), are rapidly
progressive, invariably fatal neurodegenerative conditions with no effective therapies. Their …

Prions are notorious protein-only infectious agents that cause invariably fatal brain diseases
following silent incubation periods that can span a lifetime. These diseases can arise …

Alzheimer's disease (AD) is the most prominent neurodegenerative disorder in the aging
population. It is characterized by cognitive decline, gradual neurodegeneration, and the …

Abstract Background Progression of Alzheimer's disease leads to synapse loss, neural
network dysfunction and cognitive failure. Accumulation of protein aggregates and brain …

Alzheimer's disease-related phenotypes in mice can be rescued by blockade of either
cellular prion protein or metabotropic glutamate receptor 5. We sought genetic and …

Intracellular neurofibrillary tangles (NFTs) composed of tau protein are a neuropathological
hallmark of several neurodegenerative diseases, the most common of which is Alzheimer's …

Alzheimer disease (AD) is characterized by amyloid-β accumulation, with soluble oligomers
(Aβo) being the most synaptotoxic. However, the multivalent and unstable nature of Aβo …