Non-coding RNAs: the new central dogma of cancer biology

PE Saw, X Xu, J Chen, EW Song - Science China Life Sciences, 2021 - Springer
The central dogma of molecular biology states that the functions of RNA revolve around
protein translation. Until the last decade, most researches were geared towards …

[HTML][HTML] Long non-coding RNAs: Mechanism of action and functional utility

SA Bhat, SM Ahmad, PT Mumtaz, AA Malik… - Non-coding RNA …, 2016 - Elsevier
Recent RNA sequencing studies have revealed that most of the human genome is
transcribed, but very little of the total transcriptomes has the ability to encode proteins. Long …

[HTML][HTML] LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer

Y Wang, JH Lu, QN Wu, Y Jin, DS Wang, YX Chen… - Molecular cancer, 2019 - Springer
Abstract Background Long noncoding RNAs (lncRNAs) play nonnegligible roles in the
epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that …

[HTML][HTML] Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming

J Liu, ZX Liu, QN Wu, YX Lu, CW Wong, L Miao… - Nature …, 2020 - nature.com
Tumor cells often reprogram their metabolism for rapid proliferation. The roles of long
noncoding RNAs (lncRNAs) in metabolism remodeling and the underlying mechanisms …

[HTML][HTML] cir-ITCH Plays an Inhibitory Role in Colorectal Cancer by Regulating the Wnt/β-Catenin Pathway

G Huang, H Zhu, Y Shi, W Wu, H Cai, X Chen - PloS one, 2015 - journals.plos.org
Noncoding RNAs (ncRNAs) are the dominant product of eukaryotic transcription. These
products range from short microRNAs (miRNAs) to long intergenic noncoding RNAs …

Micropeptide CIP 2A‐BP encoded by LINC 00665 inhibits triple‐negative breast cancer progression

B Guo, S Wu, X Zhu, L Zhang, J Deng, F Li… - The EMBO …, 2020 - embopress.org
TGF‐β signaling pathway plays a key role in breast cancer metastasis. Recent studies
suggest that TGF‐β regulates tumor progression and invasion not only via transcriptional …

Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation

J Zheng, X Huang, W Tan, D Yu, Z Du, J Chang, L Wei… - Nature …, 2016 - nature.com
Genome-wide association studies have identified several loci associated with pancreatic
cancer risk; however, the mechanisms by which genetic factors influence the development of …

A novel micropeptide encoded by Y-linked LINC00278 links cigarette smoking and AR signaling in male esophageal squamous cell carcinoma

S Wu, L Zhang, J Deng, B Guo, F Li, Y Wang, R Wu… - Cancer research, 2020 - AACR
Long noncoding RNAs (lncRNA) have been shown to play critical roles in many diseases,
including esophageal squamous cell carcinoma (ESCC). Recent studies have reported that …

[HTML][HTML] Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma

YS Tong, XW Wang, XL Zhou, ZH Liu, TX Yang… - Molecular cancer, 2015 - Springer
Background Recent studies have demonstrated that long non-coding RNAs (lncRNAs) were
present in the blood of cancer patients and have shown great potential as powerful and non …

[HTML][HTML] Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma

L Hu, Y Wu, D Tan, H Meng, K Wang, Y Bai… - Journal of experimental & …, 2015 - Springer
Abstract Background Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1)
has been demonstrated to be an important player in various human malignancies; it is …