Non-coding RNAs: the new central dogma of cancer biology
The central dogma of molecular biology states that the functions of RNA revolve around
protein translation. Until the last decade, most researches were geared towards …
protein translation. Until the last decade, most researches were geared towards …
[HTML][HTML] Long non-coding RNAs: Mechanism of action and functional utility
Recent RNA sequencing studies have revealed that most of the human genome is
transcribed, but very little of the total transcriptomes has the ability to encode proteins. Long …
transcribed, but very little of the total transcriptomes has the ability to encode proteins. Long …
[HTML][HTML] LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer
Y Wang, JH Lu, QN Wu, Y Jin, DS Wang, YX Chen… - Molecular cancer, 2019 - Springer
Abstract Background Long noncoding RNAs (lncRNAs) play nonnegligible roles in the
epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that …
epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that …
[HTML][HTML] Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming
J Liu, ZX Liu, QN Wu, YX Lu, CW Wong, L Miao… - Nature …, 2020 - nature.com
Tumor cells often reprogram their metabolism for rapid proliferation. The roles of long
noncoding RNAs (lncRNAs) in metabolism remodeling and the underlying mechanisms …
noncoding RNAs (lncRNAs) in metabolism remodeling and the underlying mechanisms …
[HTML][HTML] cir-ITCH Plays an Inhibitory Role in Colorectal Cancer by Regulating the Wnt/β-Catenin Pathway
G Huang, H Zhu, Y Shi, W Wu, H Cai, X Chen - PloS one, 2015 - journals.plos.org
Noncoding RNAs (ncRNAs) are the dominant product of eukaryotic transcription. These
products range from short microRNAs (miRNAs) to long intergenic noncoding RNAs …
products range from short microRNAs (miRNAs) to long intergenic noncoding RNAs …
Micropeptide CIP 2A‐BP encoded by LINC 00665 inhibits triple‐negative breast cancer progression
B Guo, S Wu, X Zhu, L Zhang, J Deng, F Li… - The EMBO …, 2020 - embopress.org
TGF‐β signaling pathway plays a key role in breast cancer metastasis. Recent studies
suggest that TGF‐β regulates tumor progression and invasion not only via transcriptional …
suggest that TGF‐β regulates tumor progression and invasion not only via transcriptional …
Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation
Genome-wide association studies have identified several loci associated with pancreatic
cancer risk; however, the mechanisms by which genetic factors influence the development of …
cancer risk; however, the mechanisms by which genetic factors influence the development of …
A novel micropeptide encoded by Y-linked LINC00278 links cigarette smoking and AR signaling in male esophageal squamous cell carcinoma
Long noncoding RNAs (lncRNA) have been shown to play critical roles in many diseases,
including esophageal squamous cell carcinoma (ESCC). Recent studies have reported that …
including esophageal squamous cell carcinoma (ESCC). Recent studies have reported that …
[HTML][HTML] Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma
YS Tong, XW Wang, XL Zhou, ZH Liu, TX Yang… - Molecular cancer, 2015 - Springer
Background Recent studies have demonstrated that long non-coding RNAs (lncRNAs) were
present in the blood of cancer patients and have shown great potential as powerful and non …
present in the blood of cancer patients and have shown great potential as powerful and non …
[HTML][HTML] Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma
L Hu, Y Wu, D Tan, H Meng, K Wang, Y Bai… - Journal of experimental & …, 2015 - Springer
Abstract Background Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1)
has been demonstrated to be an important player in various human malignancies; it is …
has been demonstrated to be an important player in various human malignancies; it is …