Over the past decade, the amount of research and the number of publications on
associations between circulating small and long non-coding RNAs (ncRNAs) and cancer …

Blood is the most interesting tissue for molecular analysis in a wide range of diseases since
it provides accumulative information of the whole body state. Transcriptomic analysis of the …

Numerous methodologies are used for blood RNA extraction, and large quantitative
differences in recovered RNA content are reported. We evaluated three archived data sets to …

Peripheral Blood gene expression is widely used in the discovery of biomarkers and
development of therapeutics. Recently, a spate of commercial blood collection and …

Recent initiatives to improve translation of findings from animal models to human disease
have focussed on reproducibility but quantifying the relevance of animal models remains a …

Purpose To evaluate the performance of FKBP5 as a cortisol activity biomarker in patients
with ACTH-dependent Cushing syndrome (CS). Methods This was a prospective …

Background PCR can be positive weeks after effective malaria treatment, potentially leading
to over diagnose of recrudescence and re-infections. The DNA detected by PCR post …

Animal models provide useful information on mechanisms in human disease conditions, but
also on exploring (patho) physiological factors affecting pharmacokinetics, safety, and …

When sequencing small RNA libraries derived from whole blood, the most abundant
microRNAs (miRs) detected are often miR-486-5p, miR-451a, and miR-92a-3p. These …

The mitochondrion is a multifunctional organelle that modulates multiple systems critical for
homeostasis during pathophysiological stress. Variation in mitochondrial DNA (mtDNA) …