Roles of the microbiota of the female reproductive tract in gynecological and reproductive health

B Zhu, Z Tao, L Edupuganti, MG Serrano… - … and Molecular Biology …, 2022 - Am Soc Microbiol
The microbiome of the female reproductive tract defies the convention that high biodiversity
is a hallmark of an optimal ecosystem. Although not universally true, a homogeneous …

Host–vaginal microbiota interactions in the pathogenesis of bacterial vaginosis

CA Muzny, P Łaniewski, JR Schwebke… - Current opinion in …, 2020 - journals.lww.com
Elucidating the cause of bacterial vaginosis has important implications for diagnosis and
treatment. Our current bacterial vaginosis pathogenesis model provides a framework for key …

Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation

SM Bloom, NA Mafunda, BM Woolston… - Nature …, 2022 - nature.com
Vaginal microbiota composition affects many facets of reproductive health. Lactobacillus
iners-dominated microbial communities are associated with poorer outcomes, including …

Metronidazole treatment rapidly reduces genital inflammation through effects on bacterial vaginosis–associated bacteria rather than lactobacilli

E Armstrong, A Hemmerling, S Miller… - The Journal of …, 2022 - Am Soc Clin Investig
Background Bacterial vaginosis (BV) causes genital inflammation and increases HIV risk,
whereas a vaginal microbiota dominated by Lactobacillus species is associated with …

Sustained effect of LACTIN-V (Lactobacillus crispatus CTV-05) on genital immunology following standard bacterial vaginosis treatment: results from a randomised …

E Armstrong, A Hemmerling, S Miller, KE Burke… - The Lancet …, 2022 - thelancet.com
Background Bacterial vaginosis might increase HIV risk by eliciting genital inflammation and
epithelial barrier disruption, whereas vaginal Lactobacillus crispatus is associated with …

Human microbiota research in Africa: a systematic review reveals gaps and priorities for future research

I Allali, RE Abotsi, LA Tow, L Thabane, HJ Zar… - Microbiome, 2021 - Springer
Background The role of the human microbiome in health and disease is an emerging and
important area of research; however, there is a concern that African populations are under …

Interactions between microbiota and cervical epithelial, immune, and mucus barrier

M Dong, Y Dong, J Bai, H Li, X Ma, B Li… - Frontiers in cellular …, 2023 - frontiersin.org
The female reproductive tract harbours hundreds of bacterial species and produces
numerous metabolites. The uterine cervix is located between the upper and lower parts of …

[HTML][HTML] Vaginal Lactobacillus fatty acid response mechanisms reveal a metabolite-targeted strategy for bacterial vaginosis treatment

M Zhu, MW Frank, CD Radka, S Jeanfavre, J Xu… - Cell, 2024 - cell.com
Bacterial vaginosis (BV), a common syndrome characterized by Lactobacillus-deficient
vaginal microbiota, is associated with adverse health outcomes. BV often recurs after …

Defining the relationship between vaginal and urinary microbiomes

YM Komesu, DL Dinwiddie, HE Richter… - American journal of …, 2020 - Elsevier
Background Although the vaginal and urinary microbiomes have been increasingly well-
characterized in health and disease, few have described the relationship between these …

Associations between the vaginal microbiome and Candida colonization in women of reproductive age

BA Tortelli, WG Lewis, JE Allsworth… - American journal of …, 2020 - Elsevier
Background The composition of bacteria within the vaginal microbiome has garnered a lot of
recent attention and has been associated with reproductive health and disease. Despite the …