Sulfur plays a critical role for the development and maintenance of life on earth, which is
reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this …

Utilization of O2 as an abundant and environmentally benign oxidant is of great interest in
the design of bioinspired synthetic catalytic oxidation systems. Metalloenzymes activate O2 …

Amide bonds occur in over half of target compounds in medicinal chemistry patents, making
amide bond formation the most commonly performed reaction in the pharmaceutical …

Mononuclear non-heme Fe (II)-and 2-oxoglutarate (2OG)-dependent oxygenases comprise
a large family of enzymes that utilize an Fe (IV)-oxo intermediate to initiate diverse oxidative …

The development and application of efficient, convenient, selective, and environmentally
benign synthetic methods is highly desirable in organic chemistry. With this requirement …

Selective functionalization of unactivated C–H bonds, water oxidation, and dioxygen
reduction are extremely important reactions in the context of finding energy carriers and …

The area of biocatalysis itself is in rapid development, fueled by both an enhanced
repertoire of protein engineering tools and an increasing list of solved problems …

Iron is an especially important redox-active cofactor in biology because of its ability to
mediate reactions with atmospheric O2. Iron-dependent oxygenases exploit this earth …

High-valent iron-oxo intermediates have often been implicated, and in some cases
identified, as the active oxidant in oxygen activating nonheme iron enzymes. Recent …

There have been significant advances in our understanding of mononuclear nonheme iron
oxygenases since our 1996 Chemical Reviews article, 1 promoted in large part by the many …