Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and
indole pathways. A variety of bioactive compounds produced via Trp metabolism can …

Abstract Treatment of cancers has always been a challenge for physicians. Typically,
several groups of anti-cancer medications are needed for effective management of an …

Bispecific T-cell engagers (BiTEs) are very effective in recruiting and activating T cells. We
tested the cytotoxicity of the CD33/CD3 BiTE antibody construct AMG 330 on primary acute …

Increased inflammation and reduced neurogenesis have been associated with the
pathophysiology of major depression. Here, we show for the first time how IL-1β, a pro …

Abstract Purpose of Review Immune checkpoint therapy has dramatically changed the
therapeutic landscape of solid malignancies. Here, we review the scientific rationale and …

Microenvironmental factors contribute to the immune dysfunction characterizing acute
myeloid leukemia (AML). Indoleamine 2, 3-dioxygenase 1 (IDO1) is an interferon (IFN)-γ …

Acute myeloid leukaemia (AML) is an aggressive blood cancer caused by the proliferation of
immature myeloid cells. The genetic abnormalities underlying AML affect signal transduction …

Introduction While current treatment for acute myeloid leukemia is characterized by high
response rates, patients' long‐term outcome is still disappointing, due to frequent relapse …

Myelodysplastic syndromes (MDS) are malignant hematopoietic stem cell disorders that
have the capacity to progress to acute myeloid leukemia (AML). Accumulating evidence …

Most leukemia patients experience little benefit from immunotherapy, in part due to the
immunosuppressive bone marrow microenvironment. Various metabolic mechanisms …