Anticancer effect of rationally designed α-helical amphiphilic peptides
F Pan, Y Li, Y Ding, S Lv, R You, R Hadianamrei… - Colloids and Surfaces B …, 2022 - Elsevier
Anticancer peptides (ACPs) have attracted increasing attention in cancer therapy due to
their unique mechanism of action on cancer cells. The main challenge is to establish the …
their unique mechanism of action on cancer cells. The main challenge is to establish the …
Therapeutic approaches using host defence peptides to tackle herpes virus infections
H Jenssen - Viruses, 2009 - mdpi.com
One of the most common viral infections in humans is caused by herpes simplex virus
(HSV). It can easily be treated with nucleoside analogues (eg, acyclovir), but resistant strains …
(HSV). It can easily be treated with nucleoside analogues (eg, acyclovir), but resistant strains …
Adjuvating the adjuvant: facilitated delivery of an immunomodulatory oligonucleotide to TLR9 by a cationic antimicrobial peptide in dendritic cells
MC Aichinger, M Ginzler, J Weghuber, L Zimmermann… - Vaccine, 2011 - Elsevier
IC31® is a novel bi-component vaccine adjuvant consisting of the peptide KLKL5KLK (KLK)
and the TLR9 agonist oligonucleotide d (IC) 13 (ODN1a). While membrane-interacting …
and the TLR9 agonist oligonucleotide d (IC) 13 (ODN1a). While membrane-interacting …
The toxic alpha‐gliadin peptide 31–43 enters cells without a surface membrane receptor
G Paolella, M Lepretti, S Martucciello… - Cell biology …, 2018 - Wiley Online Library
Abstract Alpha‐gliadin peptide 31–43 is considered to be the main peptide responsible for
the innate immune response in celiac disease patients. Recent evidence indicates that …
the innate immune response in celiac disease patients. Recent evidence indicates that …
The two-component adjuvant IC31® boosts type i interferon production of human monocyte-derived dendritic cells via ligation of endosomal TLRs
The aim of this study was to characterize and identify the mode of action of IC31®, a two-
component vaccine adjuvant. We found that IC31® was accumulated in human peripheral …
component vaccine adjuvant. We found that IC31® was accumulated in human peripheral …
[HTML][HTML] Cationic amphipathic peptides accumulate sialylated proteins and lipids in the plasma membrane of eukaryotic host cells
J Weghuber, MC Aichinger, M Brameshuber… - … et Biophysica Acta (BBA …, 2011 - Elsevier
Cationic antimicrobial peptides (CAMPs) selectively target bacterial membranes by
electrostatic interactions with negatively charged lipids. It turned out that for inhibition of …
electrostatic interactions with negatively charged lipids. It turned out that for inhibition of …
Antimicrobial and immunostimulatory peptide, KLK, induces an increase in cytosolic Ca2+ concentration by mobilizing Ca2+ from intracellular stores
J Weghuber, AM Lipp, J Stadlbauer… - Cell biology …, 2010 - Wiley Online Library
The cationic antimicrobial immunomodulatory peptide, KLK (KLKL5KLK), exerts profound
membrane interacting properties, impacting on ultrastructure and fluidity. KLK–membrane …
membrane interacting properties, impacting on ultrastructure and fluidity. KLK–membrane …
Enhancing and tailoring the immunogenicity of vaccines with novel adjuvants
CB Fox, B Wizel, SG Reed, DT O'Hagan - Development of Novel Vaccines …, 2012 - Springer
Modern vaccine development is focused on purified subunit or recombinant antigens, which
often have excellent safety profiles but reduced immunogenicity. Adjuvants are necessary …
often have excellent safety profiles but reduced immunogenicity. Adjuvants are necessary …
[PDF][PDF] IC31® mediated induction of CD8 T cell responses
T Pritz - core.ac.uk
Antigen in combination with IC31® induced up-regulation of cytokine producing double
positive CD8+ T cells following intradermal immunization …
positive CD8+ T cells following intradermal immunization …
Erythrocytes derived microvesicles: their characterisation and potential role as delivery vectors
R Cordeiro Freezor - 2018 - repository.londonmet.ac.uk
Extracellular vesicles (EV) are heterogeneous populations of small vesicles released by
virtually all cells and are classified depending on their biogenesis and size. Microvesicles …
virtually all cells and are classified depending on their biogenesis and size. Microvesicles …