SIR2014 is the latest program of the SIR suite for crystal structure solution of small, medium
and large structures. A variety of phasing algorithms have been implemented, both ab initio …

SIR2011, the successor of SIR2004, is the latest program of the SIR suite. It can solve ab
initio crystal structures of small-and medium-size molecules, as well as protein structures …

Ab initio phasing of macromolecular structures, from the native intensities alone with no
experimental phase information or previous particular structural knowledge, has been the …

Ab initio macromolecular phasing has been so far limited to small proteins diffracting at
atomic resolution (beyond 1.2 Å) unless heavy atoms are present. We describe a general ab …

Crystallography is a major tool for structure-driven drug design, as it allows knowledge of the
3D structure of protein targets and protein–ligand complexes. However, the route for crystal …

ARCIMBOLDO solves the phase problem at resolutions of around 2 Å or better through
massive combination of small fragments and density modification. For complex structures …

C 3 symmetric chiral trimethylsumanene was enantioselectively synthesized through Pd-
catalyzed syn-selective cyclotrimerization of an enantiomerically pure iodonorbornenone …

ARCIMBOLDO solves the phase problem by combining the location of small model
fragments using Phaser with density modification and autotracing using SHELXE. Mainly …

Molecular replacement, one of the general methods used to solve the crystallographic
phase problem, relies on the availability of suitable models for placement in the unit cell of …

Since its release in September 2009, the structure-solution program ARCIMBOLDO, based
on the combination of locating small model fragments such as polyalanine α-helices with …