Cells are inherently dynamic, whether they are responding to environmental conditions or
simply at equilibrium, with biomolecules constantly being made and destroyed. Due to their …

Bacterial proteases are a promising post-translational regulation strategy in synthetic circuits
because they recognize specific amino acid degradation tags (degrons) that can be fine …

Understanding and achieving concurrent modulation of amplitude and frequency,
particularly adjusting one quantity and simultaneously sustaining the other at an invariant …

One of the key questions about gene regulatory networks is how to predict complex
dynamical properties based on the influence graph's topology. Earlier theoretical studies …

Escherichia coli is a common chassis for synthetic gene circuit studies. In addition to the
dose–response of synthetic gene circuits, the analysis of dynamic responses is also an …

Embryo development is a dynamic process governed by the regulation of timing and
sequences of gene expression, which control the proper growth of the organism. While …

Differential equation models are widely used to describe genetic regulations, predict
multicomponent regulatory circuits, and provide quantitative insights. However, it is still …

Minimal trap spaces (MTSs) capture subspaces in which the Boolean dynamics is trapped,
whatever the update mode. They correspond to the attractors of the most permissive mode …

Background Oscillatory behavior is critical to many life sustaining processes such as cell
cycles, circadian rhythms, and notch signaling. Important biological functions depend on the …

合成生物学是近年来蓬勃发展的一门涉及分子生物学, 生物工程, 微生物学,
系统生物学等多个学科新型交叉学科, 旨在利用生物学原理和工程方法创造全新的生物学系统和 …