Cancer cells reprogramme metabolism to maximize the use of nitrogen and carbon for the
anabolic synthesis of macromolecules that are required during tumour proliferation and …

The expression of the urea cycle (UC) proteins is dysregulated in multiple cancers, providing
metabolic benefits to tumor survival, proliferation, and growth. Here, we review the main …

Metabolic reprogramming by oncogenic signals promotes cancer initiation and progression.
The oncogene KRAS and tumour suppressor STK11, which encodes the kinase LKB1 …

Lung cancer is the leading cause of cancer deaths worldwide, yet there remains a lack of
specific and sensitive tools for early diagnosis and targeted therapies. High-throughput …

Hepatitis B Virus (HBV) is an Old World virus with a high mutation rate, which puts its origins
in Africa alongside the origins of Homo sapiens, and is a member of the Hepadnaviridae …

Lung adenocarcinoma (LUAD) is a highly heterogeneous disease that ranks first in
morbidity and mortality. Abnormal arginine metabolism is associated with inflammatory lung …

Abstract Cancer-associated fibroblasts (CAFs), the most abundant cells in the tumor
microenvironment, play an indispensable role in cancer initiation, progression, metastasis …

Metastasis is the major cause of high mortality in lung cancer. Exploring the underlying
mechanisms of metastasis thus holds promise for identifying new therapeutic strategies that …

Comprehensive analysis of omics data, such as genome, transcriptome, proteome,
metabolome, and interactome, is a crucial technique for elucidating the complex mechanism …

Life-threatening hyperammonemia occurs in both inherited and acquired liver diseases
affecting ureagenesis, the main pathway for detoxification of neurotoxic ammonia in …