Vitamin D, best known for its role in skeletal health, has emerged as a key regulator of innate
immune responses to microbial threat. In immune cells such as macrophages, expression of …

The SARS-CoV-2 virus responsible for the COVID-19 pandemic has generated an explosion
of interest both in the mechanisms of infection leading to dissemination and expression of …

Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone
homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been …

The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

Fibrosis is a process characterized by an excessive accumulation of the extracellular matrix
as a response to different types of tissue injuries, which leads to organ dysfunction. The …

Research carried out during the past two-decades extended the understanding of actions of
vitamin D, from regulating calcium and phosphate absorption and bone metabolism to many …

1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

Vitamin D deficiency is a prevalent condition, occurring in about 30–50% of the population,
observed across all ethnicities and among all age groups. Besides the established role of …

Importance Cohort studies have reported increased incidence of cardiovascular disease
(CVD) among individuals with low vitamin D status. To date, randomized clinical trials of …

As a consequence of epidemiological studies showing significant associations of vitamin D
deficiency with a variety of adverse extra-skeletal clinical outcomes including cardiovascular …