[HTML][HTML] Ascites and resistance to immune checkpoint inhibition in dMMR/MSI-H metastatic colorectal and gastric cancers

G Fucà, R Cohen, S Lonardi, K Shitara… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Despite unprecedented benefit from immune checkpoint inhibitors (ICIs) in
patients with mismatch repair deficient (dMMR)/microsatellite instability high (MSI-H) …

Malignant pleural effusion diagnosis and therapy

L Yang, Y Wang - Open Life Sciences, 2023 - degruyter.com
Malignant pleural effusion (MPE) is a serious complication of advanced tumor, with relatively
high morbidity and mortality rates, and can severely affect the quality of life and survival of …

A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis

Q Ma, X He, B Zhang, F Guo, X Ou, Q Yang… - … and Targeted Therapy, 2022 - nature.com
Pleural and peritoneal metastasis accompanied by malignant pleural effusion (MPE) or
malignant ascites (MA) is frequent in patients with advanced solid tumors that originate from …

Single‐cell RNA sequencing captures patient‐level heterogeneity and associated molecular phenotypes in breast cancer pleural effusions

HJ Whitfield, J Berthelet, S Mangiola… - Clinical and …, 2023 - Wiley Online Library
Abstract Background Malignant pleural effusions (MPEs) are a common complication of
advanced cancers, particularly those adjacent to the pleura, such as lung and breast cancer …

[HTML][HTML] Efficacy of immune checkpoint inhibitor with or without chemotherapy for nonsquamous NSCLC with malignant pleural effusion: A retrospective multicenter …

H Kawachi, M Tamiya, Y Taniguchi, T Yokoyama… - JTO clinical and …, 2022 - Elsevier
Introduction Malignant pleural effusion (MPE) is associated with poor treatment outcome in
patients with NSCLC receiving immune checkpoint inhibitors (ICIs). ICIs and chemotherapy …

Assessment of a large-scale unbiased malignant pleural effusion proteomics study of a real-life cohort

S Zahedi, AS Carvalho, M Ejtehadifar, HC Beck, N Rei… - Cancers, 2022 - mdpi.com
Simple Summary Pleural effusion (PE) occurs as a consequence of various pathologies.
Malignant effusion due to lung cancer is one of the most frequent causes. A method for …

Candidate tumor-specific CD8+ T cell subsets identified in the malignant pleural effusion of advanced lung cancer patients by single-cell analysis

Y Sugita, D Muraoka, A Demachi-Okamura… - …, 2024 - Taylor & Francis
Isolation of tumor-specific T cells and their antigen receptors (TCRs) from malignant pleural
effusions (MPE) may facilitate the development of TCR-transduced adoptive cellular …

Exploratory pilot study to characterize the immune landscapes of malignant pleural effusions and their corresponding primary tumors from patients with breast …

C Laberiano-Fernandez, Q Gan, SM Wang… - Journal of the American …, 2024 - Elsevier
Introduction Malignant pleural effusion (MPE) is a frequent complication of advanced
malignancies. In this pilot study, we characterized the immune landscapes of MPEs …

Differences in microenvironment of lung cancer and pleural effusions by single-cell RNA sequencing

K Mahmood, H Wang, Z Ji, CX Giovacchini, MM Wahidi… - Lung Cancer, 2024 - Elsevier
Background Direct comparison of tumor microenvironment of matched lung cancer biopsies
and pleural effusions (PE) from the same patients is critical in understanding tumor biology …

CD39 identifies a specific CD8+ T cell population in lung adenocarcinoma-related metastatic pleural effusion

L Lv, H Wang, Y Zhang, J Zhai, Y Shen, QX Qu… - BMC immunology, 2023 - Springer
Malignant pleural effusion (MPE), which is a complex microenvironment that contains
numerous immune and tumour signals, is common in lung cancer. Gene alterations, such as …