Role of microbiota-gut-brain axis in regulating dopaminergic signaling

S Hamamah, A Aghazarian, A Nazaryan, A Hajnal… - Biomedicines, 2022 - mdpi.com
Dopamine is a neurotransmitter that plays a critical role both peripherally and centrally in
vital functions such as cognition, reward, satiety, voluntary motor movements, pleasure, and …

Digital addiction and sleep

B Dresp-Langley, A Hutt - … journal of environmental research and public …, 2022 - mdpi.com
In 2020, the World Health Organization formally recognized addiction to digital technology
(connected devices) as a worldwide problem, where excessive online activity and internet …

Dopamine neuron degeneration in the Ventral Tegmental Area causes hippocampal hyperexcitability in experimental Alzheimer's Disease

E Spoleti, L La Barbera, E Cauzzi, ML De Paolis… - Molecular …, 2024 - nature.com
Early and progressive dysfunctions of the dopaminergic system from the Ventral Tegmental
Area (VTA) have been described in Alzheimer's Disease (AD). During the long pre …

Tau-driven degeneration of sleep-and wake-regulating neurons in Alzheimer's disease

CH Lew, C Petersen, TC Neylan, LT Grinberg - Sleep medicine reviews, 2021 - Elsevier
Disturbances of the sleep/wake cycle in Alzheimer's disease (AD) are common, frequently
precede cognitive decline, and tend to worsen with disease progression. Sleep is critical to …

The role of sonic hedgehog pathway in the development of the central nervous system and aging-related neurodegenerative diseases

C Yang, Y Qi, Z Sun - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
The Sonic hedgehog (SHH) pathway affects neurogenesis and neural patterning during the
development of the central nervous system. Dysregulation of the SHH pathway in the brain …

[HTML][HTML] Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson's disease

J Drouin-Ouellet, EM Legault, F Nilsson, K Pircs… - Stem Cell Reports, 2022 - cell.com
We have developed an efficient approach to generate functional induced dopaminergic (DA)
neurons from adult human dermal fibroblasts. When performing DA neuronal conversion of …

Weight loss and malnutrition in patients with Parkinson's disease: current knowledge and future prospects

K Ma, N Xiong, Y Shen, C Han, L Liu… - Frontiers in aging …, 2018 - frontiersin.org
Parkinson's Disease (PD) is currently considered a systemic neurodegenerative disease
manifested with not only motor but also non-motor symptoms. In particular, weight loss and …

Viral involvement in Alzheimer's disease

A Sait, C Angeli, AJ Doig, PJR Day - ACS chemical neuroscience, 2021 - ACS Publications
Alzheimer's disease (AD) is characterized by the presence of β-amyloid plaques (Aβ) and
neurofibrillary tangles (NFTs) in the brain. The prevalence of the disease is increasing and is …

Milk's role as an epigenetic regulator in health and disease

BC Melnik, G Schmitz - Diseases, 2017 - mdpi.com
It is the intention of this review to characterize milk's role as an epigenetic regulator in health
and disease. Based on translational research, we identify milk as a major epigenetic …

[HTML][HTML] Cholecystokinin (CCK): a neuromodulator with therapeutic potential in Alzheimer's and Parkinson's disease

N Reich, C Hölscher - Frontiers in Neuroendocrinology, 2024 - Elsevier
Cholecystokinin (CCK) is a neuropeptide modulating digestion, glucose levels,
neurotransmitters and memory. Recent studies suggest that CCK exhibits neuroprotective …