Scalable and efficient DNA sequencing analysis on different compute infrastructures aiding variant discovery

F Hanssen, MU Garcia, L Folkersen… - NAR Genomics and …, 2024 - academic.oup.com
DNA variation analysis has become indispensable in many aspects of modern biomedicine,
most prominently in the comparison of normal and tumor samples. Thousands of samples …

[HTML][HTML] Targeting the limbic system: insights into its involvement in tinnitus

A Singh, PF Smith, Y Zheng - International Journal of Molecular Sciences, 2023 - mdpi.com
Tinnitus is originally derived from the Latin verb tinnire, which means “to ring”. Tinnitus, a
complex disorder, is a result of sentient cognizance of a sound in the absence of an external …

A Systematic Review on Heritability of Sudden Sensorineural Hearing Loss

MÁ Yélamos Lorente, P Perez‐Carpena… - The …, 2024 - Wiley Online Library
Objective To assess the evidence supporting the heritability and genetic basis of sudden
sensorineural hearing loss (SSNHL). Data Source Records were extracted from PubMed …

[HTML][HTML] A Systematic Review on the Genetic Contribution to Tinnitus

P Perez-Carpena, JA Lopez-Escamez… - Journal of the …, 2024 - Springer
Purpose To assess the available evidence to support a genetic contribution and define the
role of common and rare variants in tinnitus. Methods After a systematic search and quality …

[HTML][HTML] The Relevance of Autophagy within Inner Ear in Baseline Conditions and Tinnitus-Related Syndromes

G Lazzeri, F Biagioni, M Ferrucci… - International Journal of …, 2023 - mdpi.com
Tinnitus is the perception of noise in the absence of acoustic stimulation (phantom noise). In
most patients suffering from chronic peripheral tinnitus, an alteration of outer hair cells …

[HTML][HTML] Rare Deletions or Large Duplications Contribute to Genetic Variation in Patients with Severe Tinnitus and Meniere Disease

A Escalera-Balsera, AM Parra-Perez… - Genes, 2023 - mdpi.com
Meniere disease (MD) is a debilitating disorder of the inner ear defined by sensorineural
hearing loss (SNHL) associated with episodes of vertigo and tinnitus. Severe tinnitus, which …

[HTML][HTML] Transcriptional-profile changes in the medial geniculate body after noise-induced tinnitus

P Liu, X Xue, C Zhang, H Zhou, Z Ding… - … Biology and Medicine, 2024 - ncbi.nlm.nih.gov
Tinnitus is a disturbing condition defined as the occurrence of acoustic hallucinations with
no actual sound. Although the mechanisms underlying tinnitus have been explored …

Neuron navigators: A novel frontier with physiological and pathological implications

P Sandeep, P Sharma, K Luhach, N Dhiman… - Molecular and Cellular …, 2023 - Elsevier
Neuron navigators are microtubule plus-end tracking proteins containing basic and serine
rich regions which are encoded by neuron navigator genes (NAVs). Neuron navigator …