[HTML][HTML] Cancer spheroids and organoids as novel tools for research and therapy: state of the art and challenges to guide precision medicine

S El Harane, B Zidi, N El Harane, KH Krause, T Matthes… - Cells, 2023 - mdpi.com
Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …

[HTML][HTML] Recombinant viral vectors for therapeutic programming of tumour microenvironment: Advantages and limitations

K Spunde, K Korotkaja, A Zajakina - Biomedicines, 2022 - mdpi.com
Viral vectors have been widely investigated as tools for cancer immunotherapy. Although
many preclinical studies demonstrate significant virus-mediated tumour inhibition in synergy …

Intratumoral delivery of immunotherapy to treat breast cancer: current development in clinical and preclinical studies

SM Mantooth, Y Abdou, AR Saez-Ibañez… - Frontiers in …, 2024 - frontiersin.org
Breast cancer poses one of the largest threats to women's health. Treatment continues to
improve for all the subtypes of breast cancer, but some subtypes, such as triple negative …

[HTML][HTML] Establishment and Characterization of Free-Floating 3D Macrophage Programming Model in the Presence of Cancer Cell Spheroids

K Korotkaja, J Jansons, K Spunde, Z Rudevica… - International Journal of …, 2023 - mdpi.com
Reprogramming of tumor-associated macrophages (TAMs) is a promising strategy for
cancer immunotherapy. Several studies have shown that cancer cells induce/support the …

3D Coculture between Cancer Cells and Macrophages: From Conception to Experimentation

R Quoniou, E Moreau, F Cachin… - ACS Biomaterials …, 2023 - ACS Publications
A tumor is a complex cluster with many types of cells in the microenvironment that help it
grow. Macrophages, immune cells whose main role is to maintain body homeostasis …

[HTML][HTML] Fibronectin functions as a selective agonist for distinct toll-like receptors in triple-negative breast Cancer

A Ambesi, P Maddali, PJ McKeown-Longo - Cells, 2022 - mdpi.com
The microenvironment of tumors is characterized by structural changes in the fibronectin
matrix, which include increased deposition of the EDA isoform of fibronectin and the …

[HTML][HTML] Proceedings of the Online Conference “Vaccines and Vaccination during and Post COVID Pandemics”(7–9 December 2022)

L Sokolovska, M Isaguliants, FM Buonaguro - 2023 - mdpi.com
The COVID-19 pandemic put focus on various aspects of vaccine research and
development. These include mass vaccination strategies, vaccination compliance and …

[HTML][HTML] Analysis of a new therapeutic target and construction of a prognostic model for breast cancer based on ferroptosis genes

Q Li, H Liu, Y Jin, Y Yu, Y Wang, D Wu, Y Guo… - Computers in Biology …, 2023 - Elsevier
Breast cancer, which is the most common malignant tumor among women worldwide and an
important cause of death in women. The existing prognostic model for patients with breast …

[HTML][HTML] Styrylpyridinium Derivatives for Fluorescent Cell Imaging

R Putralis, K Korotkaja, M Kaukulis, Z Rudevica… - Pharmaceuticals, 2023 - mdpi.com
A set of styrylpyridinium (SP) compounds was synthesised in order to study their
spectroscopic and cell labelling properties. The compounds comprised different electron …

[HTML][HTML] Perspective Technologies of Vaccination: Do We Still Need Old Vaccines?

M Isaguliants, FJ Burt - Vaccines, 2022 - mdpi.com
Until December 2019, we were living in the world of successfully functioning vaccines and
vaccination programs. Smallpox was eradicated, polio close to being eradicated, HBV …