Macrocycles have long been recognized as useful chemical entities for medicine, with
naturally occurring and synthetic macrocycles clinically approved for use as prescription …

Natural products are embedded with structural motifs that inspire practitioners of synthetic
organic chemistry. The development of new synthetic methods and strategies for the …

Nitriles are found in many bioactive compounds, and are among the most versatile
functional groups in organic chemistry. Despite many notable recent advances, however …

The enantio‐and chemoselective iridium‐catalyzed N‐allylation of oximes is described for
the first time. Intramolecular kinetic resolution provides access to cyclic nitrones and …

The preparation of tricyclic amines from acyclic precursors is described using a cascade of
tandem reactions involving condensation of an aldehyde with a primary amine, cyclization …

The synthesis of (±)-histrionicotoxin has been achieved in just nine steps using a two-
directional synthesis strategy. Key reactions include a two-directional cross-metathesis, a …

The total synthesis of the spiropiperidine alkaloid (−)‐perhydrohistrionicotoxin (perhydro‐
HTX) 2 has been accomplished on a gram scale by employing both conventional batch …

Covering: up to June 2006 This article brings together for the first time reviews of all the
synthetic attempts towards the spirocyclic histrionicotoxin alkaloids published since the …

Verticilide (1) is a 24-membered cyclic depsipeptide isolated from the culture broth of
Verticillium sp. FKI-1033. It inhibits ryanodine binding to ryanodine receptor (RyR) and has …

A tandem one-pot reaction involving a condensation, then cyclization (N-alkylation),
followed by an azomethine ylide or nitrone dipolar cycloaddition allows a synthesis of …