Multiscale computing for science and engineering in the era of exascale performance

AG Hoekstra, B Chopard, D Coster… - … of the Royal …, 2019 - royalsocietypublishing.org
In this position paper, we discuss two relevant topics:(i) generic multiscale computing on
emerging exascale high-performing computing environments, and (ii) the scaling of such …

Review of in silico models of cerebral blood flow in health and pathology

S Payne, TI Józsa, WK El-Bouri - Progress in Biomedical …, 2023 - iopscience.iop.org
In this review, we provide a summary of the state-of-the-art in the in silico modelling of
cerebral blood flow (CBF) and its application in in silico clinical trials. CBF plays a key role in …

Multi-GPU immersed boundary method hemodynamics simulations

J Ames, DF Puleri, P Balogh, J Gounley… - Journal of computational …, 2020 - Elsevier
Large-scale simulations of blood flow that resolve the 3D deformation of each comprising
cell are increasingly popular owing to algorithmic developments in conjunction with …

Red blood cell and platelet diffusivity and margination in the presence of cross-stream gradients in blood flows

G Závodszky, B van Rooij, B Czaja, V Azizi… - Physics of …, 2019 - pubs.aip.org
The radial distribution of cells in blood flow inside vessels is highly non-homogeneous. This
leads to numerous important properties of blood, yet the mechanisms shaping these …

Haemodynamic flow conditions at the initiation of high-shear platelet aggregation: a combined in vitro and cellular in silico study

BJM Van Rooij, G Závodszky… - Interface …, 2021 - royalsocietypublishing.org
The influence of the flow environment on platelet aggregation is not fully understood in high-
shear thrombosis. The objective of this study is to investigate the role of a high shear rate in …

Numerical investigation of the effects of red blood cell cytoplasmic viscosity contrasts on single cell and bulk transport behaviour

M De Haan, G Zavodszky, V Azizi, AG Hoekstra - Applied Sciences, 2018 - mdpi.com
In-silico cellular models of blood are invaluable to gain understanding about the many
interesting properties that blood exhibits. However, numerical investigations that focus on …

Parallel performance analysis of bacterial biofilm simulation models

MV Sheraton, PMA Sloot - … International Conference, Wuxi, China, June 11 …, 2018 - Springer
Modelling and simulation of bacterial biofilms is a computationally expensive process
necessitating use of parallel computing. Fluid dynamics and advection-consumption models …

Inverse uncertainty quantification of a cell model using a gaussian process metamodel

K de Vries, A Nikishova, B Czaja… - International Journal …, 2020 - dl.begellhouse.com
In order to accurately describe the mechanics of red blood cells (RBCs) and resulting fluid
dynamics, a cell-resolved blood flow fluid solver is required. The parameters of the material …

Building a fine-grained analytical performance model for complex scientific simulations

J van Dijk, G Zavodszky, AL Varbanescu… - … Conference on Parallel …, 2022 - Springer
Analytical performance models are powerful for understanding and predicting the
performance of large-scale simulations. As such, they can help identify performance …

Cellular Blood Flow Modeling with HemoCell

G Zavodszky, C Spieker, B Czaja… - … Performance Computing for …, 2023 - Springer
Many of the intriguing properties of blood originate from its cellular nature. Bulk effects, such
as viscosity, depend on the local shear rates and on the size of the vessels. While empirical …