I. Executive Summary Background The 5 years since the publication of the first International
Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed …

Patients with severe asthma represent a minority of the total asthma population, but carry a
majority of the morbidity and healthcare costs. Achieving better asthma control in this group …

Chronic rhinosinusitis (CRS) is an inflammatory disease of the sinonasal mucosa. It is likely
due to a dysregulated immune response directed against, and also modified by, antigens …

Rhinosinusitis is one of the most common reasons for adult outpatient antibiotic
prescriptions, though there is little clinical evidence to support this practice, especially for …

Objective To assess the prognostic factors that predict favorable outcomes of low‐dose
macrolides (LDMs) in treating chronic rhinosinusitis (CRS). Methods Randomized controlled …

Objectives To explore general practitioner (GP) and ears, nose and throat (ENT) specialist
perspectives of current treatment strategies for chronic rhinosinusitis (CRS) and care …

Background Chronic rhinosinusitis (CRS) is a common source of ill health; 11% of UK adults
reported CRS symptoms in a worldwide population study. Guidelines are conflicting …

Background Chronic rhinosinusitis (CRS) is the downstream manifestation of
heterogeneous pathophysiologic mechanisms leading to chronic sinonasal inflammation …

Various chronic inflammatory airway diseases can be treated with low-dose, long-term
(LDLT) macrolide therapy. LDLT macrolides can be one of the therapeutic options for …

Objective Previous in vitro transcriptomic profiling suggests azithromycin exerts its effects in
patients with chronic rhinosinusitis (CRS) via modulation of type 1 inflammation and …